酰基辅酶A硫酯酶7（英语：Acyl-CoA thioesterase 7）是一种在人类中由ACOT7基因编码的酶。 [5] [6] [7] [8] 该基因编码酰基 辅酶家族的一个成员。编码的蛋白质水解 棕榈酰辅酶A的辅酶A 硫酯和其他长链脂肪酸。该基因表达的减少可能与内侧颞叶癫痫有关。

2024年12月24日 · ACOT7 (Acyl-CoA Thioesterase 7) is a Protein Coding gene. Diseases associated with ACOT7 include Temporal Lobe Epilepsy and Pontocerebellar Hypoplasia, Type 16. Among its related pathways are Metabolism and Fatty acid metabolism.

2017年5月18日 · Acyl-CoA thioesterase 7 (ACOT7) is a major isoform of the ACOT family that catalyzes hydrolysis of fatty acyl-CoAs to free fatty acids and CoA-SH. However, canonical...

Cytosolic acyl coenzyme A thioester hydrolase is an enzyme that in humans is encoded by the ACOT7 gene. [5][6][7][8] This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids.

酰基-CoA硫酯酶7（ACOT7）是ACOT家族的主要同工型，可催化脂肪酰基-CoA水解为游离脂肪酸和CoA-SH。 但是，ACOT7的规范和非规范功能仍有待发现。 在这项研究中，首次显示ACOT7以时间和剂量依赖的方式对遗传毒性应激（例如电离辐射（IR）和抗癌药阿霉素）有反应。 ACOT7敲低通过激活p53-p21信号传导途径诱导细胞停滞，而没有DNA损伤反应。 PKCζ作为MCF7人乳腺癌和A549人肺癌细胞中p53-p21信号通路的上游分子，特别参与了ACOT7耗竭介 …

2024年8月29日 · 神经系统功能：acot7在脑中高表达，参与神经元功能的维持和神经递质的代谢 调控，可能对神经保护具有重要作用。 抗氧化作用：ACOT7在防止长链酰基辅酶A积累引起的氧化应激中可能发挥作用，

Gene ID: 11332, updated on 9-Feb-2025. This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids. Decreased expression of this gene may …

编码的蛋白质水解棕榈酰辅酶 A 和其他长链脂肪酸的辅酶 A 硫酯。 该基因表达减少可能与内侧颞叶癫痫有关。 编码具有不同亚细胞位置的不同亚型的选择性剪接转录变体已经被表征。 [RefSeq 提供，2008 年 7 月] This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and Other long-chain fatty acids.

Acyl-CoA thioesterase 7 (ACOT7) is an intracellular enzyme that converts acyl-CoAs to FFAs. ACOT7 is induced by lipopolysaccharide (LPS); thus, we investigated downstream effects of LPS-induced induction of ACOT7 and its role in inflammatory settings in myeloid cells.

ACOT7 is a novel oncogene and therapeutic target for lung adenocarcinoma. Background: Acyl-CoA thioesterase 7 (ACOT7) is of great significance in regulating cell cycle, cell proliferation, and glucose metabolism. The function of ACOT7 in pan-cancer and its capacity as a prognostic indicator in lung adenocarcinoma (LUAD) remains unknown.