2024年12月24日 · ACOT8 (Acyl-CoA Thioesterase 8) is a Protein Coding gene. Diseases associated with ACOT8 include Flinders Island Spotted Fever and Alpha-Methylacyl-Coa Racemase Deficiency. Among its related pathways are Peroxisomal lipid metabolism and Bile acid and bile salt metabolism.

Acyl-coenzyme A thioesterase 8 is an enzyme that in humans is encoded by the ACOT8 gene. [5] [6] [7] [8] [9] The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation.

2023年11月27日 · ACOT8（Acyl-CoA Thioesterase 8）重组蛋白是细胞生物学和代谢研究的关键因素。 作为一种脂肪酸硫酯酶，ACOT8在调节脂质代谢和维持细胞内脂质平衡中扮演着重要角色。

由该基因编码的蛋白质是一种过氧化物酶体硫酯酶，它似乎更多地参与脂肪酸的氧化而不是它们的形成。 编码的蛋白质可以与人类免疫缺陷病毒 1 蛋白 Nef 结合，并介导 Nef 诱导的 T 细胞中 CD4 的下调。 [RefSeq 提供，2010 年 10 月] The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in …

2012年9月1日 · ACOT8 is a highly conserved protein that is expressed from bacteria to man, including yeast and plants but apparently not in insects. The bacterial homolog TEII, which shows about 40% sequence identity to human ACOT8, hydrolyzes medium- …

2025年2月8日 · Acyl-CoA thioesterase 8 is a specific protein related to nodal metastasis and prognosis of lung adenocarcinoma. An isoform of long-chain acyl-CoA hydrolase may be responsible for the nafamostat hydrolysis in human liver cytosol. SREBP2 modulates brain palmitoyl-coa hydrolase gene transcription.

2021年1月15日 · 最后，研究人员指出， acot11和acot8分别是ccrcc诊断和预后的有前景的生物标志物，acot8可能通过调节oxphos和铁死亡影响ccrcc的发展和恶化 。 他们的发现可能为ccRCC的 精准 诊断和个性化治疗提供新的策略。

ACOT8 is a peroxisomal protein with broad substrate specificity, including medium-to long-chain and methyl branched acyl-CoAs, intermediates of β-oxidation and bile acid-CoAs (see Text Box). The activity is inhibited by CoA and expression is upregulated by fasting and PPARα activation [ 42 ] and ACOT8 overexpression leads to peroxisomal ...

2024年9月12日 · Fatty acid metabolic enzyme acyl-CoA thioesterase 8 promotes the development of hepatocellular carcinoma. Acyl-CoA thioesterase 8 is a specific protein related to nodal metastasis and prognosis of lung adenocarcinoma. Jung WY, Kim YH, Ryu YJ, Kim BH, Shin BK, Kim A, Kim HKJung WY, et al. Pathol Res Pract, 2013 May. PMID 23540296.

acot8的详细信息，包括基因名称，代码，染色体位置，相互作用关系和通路，简述为由该基因编码的蛋白质是出现更多的脂肪酸的氧化，而不是在它们的形成参与过氧化物酶体硫酯酶。