2024年12月24日 · ACOX2 (Acyl-CoA Oxidase 2) is a Protein Coding gene. Diseases associated with ACOX2 include Bile Acid Synthesis Defect, Congenital, 6 and Abdominal Obesity-Metabolic Syndrome 1. Among its related pathways are Bile acid and bile salt metabolism and Peroxisomal lipid metabolism.

酰基辅酶A氧化酶2 (ACOX2) 是细胞过氧化物酶体中同时负责催化支链脂肪酸氧化和胆汁酸合成的重要限速酶。 复旦大学附属妇产科医院 周翔宇研究员 等人前期已发现 ACOX2基因胚系突变是致糖脂能量代谢转换的潜在效应因子 [1], 并显著下调肝细胞 尼克酰胺-N-甲基转移酶 (NNMT) 及其代谢产物1-甲基烟酰胺的表达水平 [2]，提示ACOX2在代谢调控中的重要作用，但具体的发生机制还有待深入解析。

2022年3月29日 · Acyl-CoA oxidase 2 (Acox2) is an enzyme involved in peroxisomal bile acid synthesis and branched-chain fatty acid degradation. Acox2 knockout (−/−) mice...

Using exome sequencing, we describe a syndrome associated with homozygous loss of Acyl CoA Oxidase 2 (ACOX2) featuring elevated transaminase levels, liver fibrosis, ataxia, and cognitive impairment. ACOX2 encodes the peroxisomal branched-chain acyl-CoA oxidase and is involved in the bile acid biosynthetic pathway. Importantly, this disorder is ...

Acyl-CoA oxidase 2 (ACOX2) is a novel gene in subnetwork1, encodes a peroxisomal enzyme, and its function in HCC was investigated in vivo and in vitro. The lower expression of ACOX2 was validated by real-time quantitative PCR, immunohistochemistry, and Western blot.

它编码支链酰基辅酶 A 氧化酶，该酶参与过氧化物酶体中长支链脂肪酸和胆汁酸中间体的降解。 这种酶的缺乏会导致支链脂肪酸和胆汁酸中间体的积累，并可能导致齐薇格综合征、严重的认知障碍和儿童死亡。 [RefSeq 提供，2009 年 3 月] The product of this gene belongs to the acyl-CoA oxidase family. It encodes the branched-chain acyl-CoA oxidase which is involved in the degradation of long branched fatty acids and bile acid intermediates in peroxisomes.

ACOX2 is a prognostic marker and impedes the progression of hepatocellular carcinoma via PPARalpha pathway. ACOX2, physiologically responsible for one of the stages in the degradation of branched-chain fatty acids and bile acid, may be a possible genetic risk factor linking Preeclampsia and Related Cardiovascular diseases.

2025年1月4日 · Title: ACOX2 is a prognostic marker and impedes the progression of hepatocellular carcinoma via PPARα pathway. ACOX2, physiologically responsible for one of the stages in the degradation of branched-chain fatty acids and bile acid, may be a possible genetic risk factor linking Preeclampsia and Related Cardiovascular diseases.

ACOX2基因，也被称为acyl-CoA oxidase 2，是Flavoproteins家族的一员。 这个基因位于人类染色体3p14.3，编码一个具有蛋白质产物的基因。 ACOX2在细胞中扮演着重要的角色，特别是在脂肪酸的代谢过程中。

2024年3月5日 · Clinical resource with information about ACOX2, Congenital bile acid synthesis defect 6, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.