FDX1（铁氧还蛋白还原酶 1） 是一种参与铁代谢的关键酶，它将铁还原为 Fe2+，从而使铁能够被结合到各种蛋白质中。 FDX1 还参与铜代谢，因为它可以将铜还原为 Cu+，从而使铜能够被转运到细胞内。

2023年5月8日 · Ferredoxin1 (FDX1) promotes dihydrolipoyl transacetylase (DLAT) lipoacylation and abates iron-sulfur cluster proteins by reducing Cu 2+ to Cu +, inducing cell death. Copper homeostasis depends on the copper transporter, and disturbances to …

2024年12月24日 · ACP6 (Acid Phosphatase 6, Lysophosphatidic) is a Protein Coding gene. Diseases associated with ACP6 include Opitz-Kaveggia Syndrome and Chromosome 1Q21.1 Deletion Syndrome. Among its related pathways are …

Our analysis showed that the central regulatory gene of cuproptosis, FDX1, has differential expression and modification levels in various tumors, which is associated with cellular function, immune modulation, and disease prognosis. Thus, FDX1 -dependent cuproptosis may serve as a brand-new target in future therapeutic approaches against tumors.

2023年5月16日 · Ferredoxin 1 (FDX1), a critical metabolism-related gene, has been implicated in the regulation of cuproptosis via its involvement in the destabilization of Fe-S cluster proteins...

2024年7月19日 · They identified seven genes (FDX1 and six genes involved in proteolipoylation LIAS, LIPT1, DLD, DLAT, PDHA1, and PDHB) as the key genes promoting cellular cuproptosis. The primary target of cuproptosis-induced cell death was mitochondrial dysfunction.

为了确定介导铜毒性的特定代谢途径，研究者通过多重CRISPR基因敲除筛选，确定了促进铜诱导死亡的关键基因-FDX1（该基因编码一种Elesclomol可直接靶向的蛋白，该蛋白可将二价铜离子转化更毒的一价铜离子）。

2021年8月19日 · FDX1 positively regulates a specific metabolic pathway of copperoptosis, and FDX1 and Protein lipoylation are key regulators of copper ion carrier-induced cell death. FDX1 is associated with protein thioctanoylation, and FDX1 knockout results in loss of protein thioctanoylation.

在这个过程中，Ferredoxin1 (FDX1)是铜死亡的关键因素，通过将 Cu2+还原为 Cu+，促使脱氢脂酰转乙酰酶（DLAT）脂酰化，并通过降低铜硫簇蛋白水平来引发细胞死亡。

该基因编码一种小的铁硫蛋白，通过铁氧还蛋白还原酶将电子从 NADPH 转移到线粒体细胞色素 P450，参与类固醇、维生素 D 和胆汁酸代谢。 在 20 号和 21 号染色体上发现了该功能基因的假基因。 [RefSeq 提供，2011 年 8 月] This gene encodes a small iron-sulfur protein that transfers electrons from NADPH through ferredoxin reductase to mitochondrial Cytochrome P450, involved in steroid, vitamin D, and bile acid metabolism.