腺病毒介导的ACSL1在肝癌细胞（HepG2）超表达，导致酰基辅酶A合成酶活力提高了20倍，增加了细胞中的ACSL1－CoA含量，提高了油酸在甘油三酯中的沉积（Parkes等，2006），此研究中由于肉毒碱的量没有提高而导致CPT－1活性没有增加，从而不能将更多的ACSL1－CoA转运至线粒体中进行β－氧化，因此提高ACSL1的表达量可以增加细胞内脂肪的沉积量（Mashek等，2007）。 ACSL基因家族成员在不同组织中的表达是不同的，暗示了每种ACSL成员可能在 …

2024年12月24日 · ASCL2 (Achaete-Scute Family BHLH Transcription Factor 2) is a Protein Coding gene. Diseases associated with ASCL2 include Beckwith-Wiedemann Syndrome and Colonic Benign Neoplasm. Among its related pathways are Human Early Embryo Development and Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers.

Our strategy uncovered a novel uncharacterized Acsl-like gene found in teleosts and coelacanth, which we designate Acsl2. The detailed analysis of the Acsl2 teleost gene locus strongly supports the suggestion that it corresponds to a retained paralogue, lost in other vertebrates classes (“an ohnolog gone missing”).

2021年1月5日 · In this study, we comprehensively analyzed the functional domains, motifs, gene organizations and evolutions of chicken ACSLs, identified the genomic loss of chicken ACSL2 gene via consensus conserved genomic synteny, investigated the expression profiles of ACSLs in various tissues at different developmental stages in chicken, and explored ...

2021年10月15日 · Long-chain acyl-coenzyme A synthases (ACSLs) are responsible for activating long-chain FAs and are frequently deregulated in cancers. Among the five mammalian ACSL family members, ACSL1 is involved in the TNFα-mediated pro-inflammatory phenotype and mainly facilitates cancer progression. ACSL3 is an androgen-responsive gene.

2021年10月15日 · Long-chain acyl-coenzyme A synthases (ACSLs) are responsible for activating long-chain FAs and are frequently deregulated in cancers. Among the five mammalian ACSL family members, ACSL1 is involved in the TNFα-mediated pro-inflammatory phenotype and mainly facilitates cancer progression. ACSL3 is an androgen-responsive gene.

Predicted to enable arachidonate-CoA ligase activity. Predicted to be involved in long-chain fatty acid metabolic process; long-chain fatty-acyl-CoA biosynthetic process; and very long-chain fatty acid metabolic process. Predicted to act upstream of or within fatty acid metabolic process.

长链脂酰辅酶A合成酶家族（long chain acyl-coenzyme A synthetase family, ACSLs）负责激活长链脂肪酸，在脂肪酸代谢中发挥重要作用。 但在癌细胞中，其调控作用经常被解除，细胞内脂肪酸的分布、种类和数量发生改变，进而导致癌症和其他代谢性疾病的发生。 ACSLs在哺乳动物中包括5种亚型，分别为ACSL1、3、4、5和6。...

2013年12月12日 · Our strategy uncovered a novel uncharacterized Acsl-like gene found in teleosts, spotted gar, coelacanth and possibly lamprey, which we designate Acsl2. The detailed analysis of the Acsl2 teleost gene locus strongly supports the conclusion that it corresponds to a retained 2R paralogue, lost in tetrapods.

2015年3月28日 · ACSLs on endoplasmic reticulum and mitochondrial outer membrance catalyze fatty acids with chain lengths from 12 to 20 carbon atoms to form acyl-CoAs, which are lipid metabolic intermediates and involved in fatty acid metabolism, membrane modifications and various physiological processes.