However, one member of this family, FATP2, is identical to an enzyme with very long-chain acyl-CoA synthetase (ACSVL) activity. This enzyme (ACSVL1 or FATP2), was isolated using classical protein purification techniques. In fact, the six-member ACSVL protein family is identical to the six-member FATP family.

我们观察到，对于许多 acsvl，过表达蛋白的亚细胞定位与内源蛋白的亚细胞定位不同。 使用 RNA 干扰 (siRNA)，我们敲低了 Neuro2a 细胞中 FATP4（提议名称：ACSVL5）的表达。

2021年10月15日 · Acyl-CoA synthases can be divided into very long-chain acyl-CoA synthases (ACSVL), long-chain acyl-CoA synthases (ACSL), medium-chain acyl-CoA synthases (ACSM) and short-chain acyl-CoA synthases (ACSS) based on the carbon chain length of the catalyzed FA (Tang et al., 2018).

Members of the fatty acid transport protein/very long chain acyl-CoA synthetase (FATP/Acsvl) family are emerging as key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis.

2007年6月30日 · However, one member of this family, FATP2, is identical to an enzyme with very long-chain acyl-CoA synthetase (ACSVL) activity. This enzyme (ACSVL1 or FATP2), was isolated using classical protein purification techniques. In fact, the six-member ACSVL protein family is identical to the six-member FATP family.

综述的目的 11 种长链 (ACSL) 和超长链酰基辅酶 A (acyl-CoA) 合成酶 [ (ACSVL)/脂肪酸转运蛋白] 正受到相当多的关注，因为它们的个体功能明显不多余的。 最近的发现 最近的研究集中在酰基辅酶A合成酶的结构、它们的翻译后修饰、它们激活不同链长的脂肪酸的能力，以及它们在引导脂肪酸进入不同代谢途径中的作用。 一个未解决的争议集中在 ACSVL 异构体以及它们是否同时具有酶促和转运功能。 另一个问题是脂肪酸转化为酰基辅酶A是否会增加足以激活AMP激活激酶 …

2013年7月23日 · Endogenous human ACSVL3 protein was found in a punctate subcellular compartment that partially colocalized with mitochondria as determined by immunofluorescence microscopy and subcellular fractionation. From these studies, we conclude that ACSVL3 is a promising new therapeutic target in lung cancer.

2004年12月24日 · The family of proteins that includes very long-chain acyl-CoA synthetases (ACSVL) consists of six members. These enzymes have also been designated fatty acid transport proteins. We cloned full-length mouse Acsvl3 cDNA and characterized its protein product ACSVL3/fatty acid transport protein 3.

2022年12月1日 · FATP2/ACSVL1 (very-long-chain acyl-coenzyme A (CoA) synthetase 1) is a transmembrane multifunctional protein with an ambiguous role as a transporter and ACSVL encoded by SLC27A2 (solute carrier family 27 members 2).

2011年9月2日 · We have expressed two naturally occurring splice variants of human FATP2 (Acsvl1) in yeast and 293T-REx cells and addressed their roles in fatty acid transport, activation, and intracellular trafficking.