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Wikipedia
https://en.wikipedia.org › wiki › Activin_and_inhibin
Activin and inhibin - Wikipedia
Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Identified in 1986, activin enhances FSH biosynthesis and secretion, and participates in the regulation of the menstrual cycle. Many other functions have been found to be exerted by activin, including roles in cell proliferation, differentiation, apoptosis, metabolism, homeostasis, i…
Structure
The activin and inhibin protein complexes are both dimeric in structure, and, in each complex, the two monomers are linked t… 展开
Function
Activin is produced in the gonads, pituitary gland, placenta, and other organs:
• In the ovarian follicle, activin increases FSH binding and FSH-induced aromatization. It participates in androgen synthesis enhan… 展开
Mechanism of action
As with other members of the superfamily, activins interact with two types of cell surface transmembrane receptors (Types I and II) which have intrinsic serine/threonine kinase activities in their cytoplasmic domains: … 展开
Clinical significance
Activin A is more plentiful in the adipose tissue of obese, compared to lean persons. Activin A promotes the proliferation of adipocyte progenitor cells, while inhibiting their differentiation into adipocytes. Activin A also increases in… 展开
External links
• Activin at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Inhibin at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Grusch M, Kreidl E (1 August 2008). "Activin and follis… 展开
CC-BY-SA 许可证中的维基百科文本

MCE-生物活性分子大师
https://www.medchemexpress.cn › proteins › activin-a.html
激活素 A (Activin A) | 重组蛋白 | MCE - MCE-生物活性分子大师
Activin exists in three basic molecular forms composed of two inhibin β subunits: activin A (βAβA), activin B (βBβB), and activin AB (βAβB). Activin A binds with high affinity to activin type II …
维基百科
https://zh.wikipedia.org › wiki › 激活素与抑制素
激活素与抑制素 - 维基百科，自由的百科全书
激活素（英語： Activin ，亦成为激活蛋白或活化素）与抑制素（英語： inhibin ）是一种用于抑制卵泡刺激素分泌与组合的梭氨酸 [1] 。参与在月经周期的调节中。
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Cell Communication and Signaling
https://biosignaling.biomedcentral.com › articles
Activin signaling as an emerging target for therapeutic …
2009年6月18日 · Accordingly, activin signaling may be a target for therapeutic interventions. In this review, we summarize the current knowledge on activin …
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nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
Activins and Inhibins: Roles in …
Since their original discovery as regulators of follicle-stimulating hormone (FSH) secretion and erythropoiesis, the TGF-β family members activin and inhibin have been shown to participate in …
知乎专栏
https://zhuanlan.zhihu.com
激活素A(Activin A,ACV-A) - 知乎 - 知乎专栏
2023年5月16日 · 激活素A(Activin A,ACV-A)是转化生长因子β超家族成员,是一种多功能细胞因子，多种免疫细胞可产生激活素A,如单核巨噬细胞、肥大细胞及部分淋巴细胞等。
其他用户还问了以下问题
Where is activin produced?
Activin is produced in the gonads, pituitary gland, placenta, and other organs: In the ovarian follicle, activin increases FSH binding and FSH-induced aromatization. It participates in androgen synthesis enhancing LH action in the ovary and testis. In the male, activin enhances spermatogenesis.
Activin and inhibin - Wikipedia
en.wikipedia.org
Is Activin signaling a molecular target for musculoskeletal disorders?
In this review, we summarize the current knowledge on activin signaling and discuss the potential roles of this pathway as a molecular target of therapy for metabolic diseases, musculoskeletal disorders, cancers and neural damages.
Activin signaling as an emerging target for therapeutic interventions
biosignaling.biomedcentral.com
Why is activin called activin?
The term “activin” was proposed by Roger Guillemin’s group to signify the protein’s opposition to “inhibin”, a competitive antagonist discovered a few years prior. Inhibin has a close structural likeness to activin and opposes many of its physiological effects, such as stimulation of FSH secretion [16, 17]. 2.2.2. Structure
Principles of the activin receptor signaling pathway and its inhibition
sciencedirect.com
Why is Activin signaling important?
The expression of activins, inhibins, their receptors and regulatory proteins is dynamic and widespread. Therefore, it is not surprising that activin signaling participates in a variety of biological processes that impact embryonic development, growth, as well as functions of fully differentiated cell types (Table 1). Table 1.
Activins and Inhibins: Roles in Development, Physiology, and Disease
pmc.ncbi.nlm.nih.gov
What are Activins & what do they do?
Activins are expressed in various tissues and have a broad range of activities including the regulation of gonadal function, hormonal homeostasis, growth and differentiation of musculoskeletal tissues, regulation of growth and metastasis of cancer cells, proliferation and differentiation of embryonic stem cells, and even higher brain functions.
Activin signaling as an emerging target for therapeutic interventions
biosignaling.biomedcentral.com
What is the difference between inhibins and activins?
Inhibins and activins share common β subunits, with inhibins occurring as αβ heterodimers, whereas activins are ββ homodimers. Because inhibins were discovered and isolated before activins, the β monomers are designated inhibins βA and βB, and the genes are Inhba and Inhbb, respectively.
Activins and Inhibins: Roles in Development, Physiology, and Disease
pmc.ncbi.nlm.nih.gov
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ScienceDirect
https://www.sciencedirect.com › topics › medicine-and-dentistry › activin
Activin - an overview | ScienceDirect Topics
Activins are dimeric proteins comprising two beta subunits (activin A=βAβA, activin AB=βAβB or activin B=βBβB) and containing a backbone of a cysteine-knot fold, with the monomers linked …
ScienceDirect
https://www.sciencedirect.com › science › article › pii
Principles of the activin receptor signaling pathway and its inhibition
2021年8月1日 · This review covers the anabolic and stimulatory effects of inhibiting activin, myostatin, and GDF11 in muscle, blood, and bone. It also proposes a classification of …
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
The Biology Of Activin: Recent Advances In Structure, Regulation …
Activin was discovered in the 1980’s as a gonadal protein that stimulated FSH release from pituitary gonadotropes and was thought of as a reproductive hormone. In the ensuing decades …
PubMed
https://pubmed.ncbi.nlm.nih.gov
Activin-A in the regulation of immunity in health and disease
Here, we provide an overview of the biology of activin-A and its signaling pathways, summarize recent studies pertinent to the role of activin-A in the modulation of inflammation and immunity, …
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Activin and inhibin - Wikipedia

激活素 A (Activin A) | 重组蛋白 | MCE - MCE-生物活性分子大师

激活素与抑制素 - 维基百科，自由的百科全书

Activin signaling as an emerging target for therapeutic …

Activins and Inhibins: Roles in …

激活素A(Activin A,ACV-A) - 知乎 - 知乎专栏

Activin and inhibin - Wikipedia

Activin signaling as an emerging target for therapeutic interventions

Principles of the activin receptor signaling pathway and its inhibition

Activins and Inhibins: Roles in Development, Physiology, and Disease

Activin signaling as an emerging target for therapeutic interventions

Activins and Inhibins: Roles in Development, Physiology, and Disease

Activin - an overview | ScienceDirect Topics

Principles of the activin receptor signaling pathway and its inhibition

The Biology Of Activin: Recent Advances In Structure, Regulation …

Activin-A in the regulation of immunity in health and disease

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