2024年8月4日 · Results: In AD mice, HKL improved cognitive function, relieved hippocampal Aβ 1-42 plaque deposition, promoted hippocampal neuron survival, and activated hippocampal …

在海马神经元 AD 模型中，HKL 增加神经元活性，减弱神经元凋亡和 Aβ 聚集，激活 SIRT3 和线粒体自噬，减少线粒体和神经元 ROS，并升高线粒体膜电位。 CsA治疗和3-TYP治疗消除 …

2022年1月5日 · Honokiol (HKL, C 18 H 18 O 2) is a kind of natural extraction from bark of Magnolia officinalis with anti-AD effect, and our study aims to explore the effect of HKL on …

The promotion of mitochondrial autophagy by HKL in hippocampal neuronal AD model was counteracted by 3-TYP. Conclusions: HKL activates SIRT3-mediated mitochondrial autophagy …

2018年5月31日 · In this study, we examined the possible protective effects of honokiol (HKL) on mitochondrial dysfunction induced by AβOs in neurons, and cognitive function in AD PS1 …

2024年8月4日 · In AD mice, HKL improved cognitive function, relieved hippocampal Aβ 1–42 plaque deposition, promoted hippocampal neuron survival, and activated hippocampal SIRT3 …

2024年8月4日 · In AD mice, HKL improved cognitive function, relieved hippocampal Aβ 1–42 plaque deposition, promoted hippocampal neuron survival, and activated hippocampal SIRT3 …

Honokiol (HKL) is a well-known bioactive and nutraceutical compound that can act as an antioxidant and anti-inflammatory molecule. HKL can protect against memory impairments in …

In hippocampal neuronal AD model, HKL increased neuronal activity, attenuated neuronal apoptosis and Aβ aggregation, activated SIRT3 and mitochondrial autophagy, reduced …

In hippocampal neuronal AD model, HKL increased neuronal activity, attenuated neuronal apoptosis and Aβ aggregation, activated SIRT3 and mitochondrial autophagy, reduced …