2024年8月4日 · Results: In AD mice, HKL improved cognitive function, relieved hippocampal Aβ 1-42 plaque deposition, promoted hippocampal neuron survival, and activated hippocampal SIRT3 expression and mitochondrial autophagy. These effects of HKL on AD mice were abolished by 3-TYP treatment.

在海马神经元 AD 模型中，HKL 增加神经元活性，减弱神经元凋亡和 Aβ 聚集，激活 SIRT3 和线粒体自噬，减少线粒体和神经元 ROS，并升高线粒体膜电位。 CsA治疗和3-TYP治疗消除了HKL对海马神经元AD模型的保护作用。 在海马神经元 AD 模型中 HKL 对线粒体自噬的促进作用被 3-TYP 抵消。 结论HKL 激活 SIRT3 介导的线粒体自噬以减轻 AD 中海马神经元损伤。 HKL 可能有效治疗 …

2022年1月5日 · Honokiol (HKL, C 18 H 18 O 2) is a kind of natural extraction from bark of Magnolia officinalis with anti-AD effect, and our study aims to explore the effect of HKL on mitophagy and UPR mt in AD. Briefly, male APP/PS1 mice and Aβ oligmer (AβO)-treated primary hippocampal neurons were respectively used to mimic AD in vivo and in vitro.

The promotion of mitochondrial autophagy by HKL in hippocampal neuronal AD model was counteracted by 3-TYP. Conclusions: HKL activates SIRT3-mediated mitochondrial autophagy to mitigate hippocampal neuronal damage in AD. HKL may be effective in treating AD.

2018年5月31日 · In this study, we examined the possible protective effects of honokiol (HKL) on mitochondrial dysfunction induced by AβOs in neurons, and cognitive function in AD PS1 V97L transgenic mice. We determined that HKL increased mitochondrial sirtuin 3 (SIRT3) expression levels and activity, which in turn markedly improved ATP production and weakened ...

2024年8月4日 · In AD mice, HKL improved cognitive function, relieved hippocampal Aβ 1–42 plaque deposition, promoted hippocampal neuron survival, and activated hippocampal SIRT3 expression and mitochondrial autophagy. These effects of …

2024年8月4日 · In AD mice, HKL improved cognitive function, relieved hippocampal Aβ 1–42 plaque deposition, promoted hippocampal neuron survival, and activated hippocampal SIRT3 expression and mitochondrial autophagy. These effects of …

Honokiol (HKL) is a well-known bioactive and nutraceutical compound that can act as an antioxidant and anti-inflammatory molecule. HKL can protect against memory impairments in AD mouse models. In this study, we explored whether the application of HKL was also protective against the insult of chronic cerebral hypoperfusion (CCH) in rats.

In hippocampal neuronal AD model, HKL increased neuronal activity, attenuated neuronal apoptosis and Aβ aggregation, activated SIRT3 and mitochondrial autophagy, reduced mitochondrial and ...

In hippocampal neuronal AD model, HKL increased neuronal activity, attenuated neuronal apoptosis and Aβ aggregation, activated SIRT3 and mitochondrial autophagy, reduced mitochondrial and neuronal ROS, and elevated mitochondrial membrane potential. CsA treatment and 3‐TYP treatment abrogated the protection of HKL on hippocampal neuronal AD ...