脂多糖（Lipopolysaccharide, LPS）是革兰氏阴性细菌外膜的主要成分之一，由类脂A、核心多糖和O-抗原三部分组成，其中O-抗原决定了LPS的血清型，具有重要的生物学功能和作用机制。

2019年4月8日 · The chronic administration of LPS can cause spatial memory and learning impairment analogous to the cognitive decline observed during AD, which is associated with inflammation and amyloid...

Lipopolysaccharide (LPS) is a strong immunogenic particle present in the outer membrane of Gram-negative bacteria. It is a major triggering factor for the inflammatory cascade in response to a Gram-negative bacteria infection.

2018年2月22日 · This review proposes that lipopolysaccharide (LPS, found in the wall of all Gram-negative bacteria) could play a role in causing sporadic Alzheimer's disease (AD). This is based in part upon recent studies showing that: Gram-negative E. coli bacteria can form extracellular amyloid; bacterial- …

LPS-induced inflammation is used in experimental in vitro and in vivo models of neuroinflammation and has been shown to also promote amyloid deposition in vivo [27,28]. Some studies have associated AD neuropathology with LPS levels in the brain.

2021年12月7日 · The AD pathology-related localization of LPS within the CNS suggests that LPS has unique pathological roles in AD (Table 4). Moreover, LPS is directly involved in AD pathology, including neuroinflammation through microglial TLR4 …

Rare early-onset familial forms of Alzheimer’s disease (AD) are associated with autosomal dominant mutations in the amyloid beta precursor protein (AβPP), presenilin 1 and presenilin 2 genes (Goate and Hardy, 2012).

2021年6月22日 · The study provided exciting information about the biochemical perturbations due to LPS-induced inflammation in the transgenic AD model, which can significantly enhance our understanding of the...

先前的研究表明，促炎性lps与受ad影响的脑细胞核的共定位表明，这种神经毒素可能与支持炎性神经变性和稳态基因表达失败的遗传毒性事件有关。 在此报告中，我们提供了证据，证明在零星的广告中，LPS逐渐积累在神经元实质中，并且似乎优先与神经元核的 ...

2022年10月21日 · 多个独立研究调查员已在老年的人脑中大量检测到 LPS，并且已发现受阿尔茨海默病 （AD） 影响的神经元周围和内部的 LPS 丰度增加。 微生物组产生的 LPS 和其他内毒素穿过胃肠道生物生理屏障进入体循环，并穿过血脑屏障进入大脑，这一病理过程随着衰老和血管疾病（包括“肠漏综合征”）而增加。 进一步的证据表明，LPS 上调促炎转录因子复合物 NF-kB （p50/p65），随后上调一组 NF-kB 敏感的 microRNA，包括 miRNA-30b、miRNA-34a …