2022年9月15日 · Here, we show that SIRT6, a chromatin-associated deacetylase indirectly regulates glucocorticoid-induced muscle wasting by modulating IGF/PI3K/AKT signaling. Our results show that SIRT6 levels...

SIRT6（Sirtuin 6）是一种NAD+依赖的去乙酰化酶，其被证实可对组蛋白H3K9、H3K18和H3K56进行去乙酰化修饰，进而在细胞代谢、DNA损伤修复、炎症反应以及肿瘤发生发展等多个生理进程中发挥重要作用。...

2024年12月10日 · Here, we propose a possible mechanism of AD by which SIRT6 regulates APP metabolism through the deacetylation-ubiquitination axis to reduce APP stability and Aβ plaque formation, making SIRT6 a promising therapeutic target for the treatment of AD.

2022年12月10日 · Here we show that Sirt6 deficiency exaggerates chondrocyte senescence and osteoarthritis progression, whereas intra-articular injection of adenovirus-Sirt6 markedly attenuates surgical...

2017年3月1日 · SIRT6 expression is reduced in brains of patients with Alzheimer's disease (AD), and overexpression of SIRT6 can prevent DNA damage in a mouse model of AD [96]. A decline in SIRT6 levels is also observed in aged human fibroblasts, and overexpression of SIRT6 can rescue a decline in BER efficiency in these cells [78] .

2023年10月1日 · Of the seven mammalian SIRT isotypes (SIRT1–7), SIRT1 and SIRT6 are well-recognized for regulating signaling pathways related to aging. Herein, we review the protective role of SIRT1 and SIRT6 in aging-related diseases at molecular, cellular, tissue, and whole-organism levels.

2024年12月10日 · Systemic pharmacological activation of SIRT6 ameliorated both amyloid pathology and cognitive deficits in APP/PS1 mice, a mouse model of AD. The findings demonstrate that the activity of SIRT6 destabilizes APP and suggest that activating SIRT6 has therapeutic potential to reduce amyloid-associated pathology in patients with AD.

Methods: An adenovirus containing SIRT-6 complementary DNA (Ad-SIRT6) was used to deliver SIRT-6 to human RA fibroblast-like synoviocytes in vitro as well as to mice with collagen-induced arthritis (CIA) in vivo via bilateral intraarticular injections into the ankle joints.

Sirt6 is one such gene that not only regulates DNA repair, but also maintains epigenomic stability and promotes longevity. Specifically, SIRT6 promotes base excision repair (Mostoslavsky et al., 2006) and both the homologous recombination (HR) and the non-homologous end joining (NHEJ) pathways of DSB repair (Mao et al., 2011; Toiber et al., 2013).

2022年4月21日 · Sirt6 is an important nicotinamide adenine dinucleotide (NAD) + -dependent histone deacetylase. Belonging to the Sirtuins family, Sirt6 affects biological processes, e.g., by delaying aging, inhibiting inflammation and stabilizing the genome [16].