2024年12月24日 · ADAM19 (ADAM Metallopeptidase Domain 19) is a Protein Coding gene. Diseases associated with ADAM19 include Fanconi Renotubular Syndrome 1 and Alzheimer's Disease. Among its related pathways are Cell junction organization and Regulation of CDH11 Expression and Function.

ADAM19 (A D isintegrin A nd M etalloproteinase 19, MADDAM, meltrin beta), is a human gene. [5] This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family.

To determine the potential novel role of ADAM19 in the metabolic syndrome, we first conducted microarray studies on peripheral blood mononuclear cells from a well-characterised human cohort. Secondly, we examined the expression of ADAM19 in liver and gonadal white adipose tissue using an in vivo diet induced obesity mouse model.

ADAM19 is a protective factor for human prostate cancer. Further, this study suggests that upregulation of ADAM19 expression could be of therapeutic potential in human prostate cancer. these findings suggested that miR-145 functions as a tumor suppressor in RB by directly targeting ADAM19 in retinoblastoma cells

该成员是 I 型跨膜蛋白，可作为树突状细胞分化的标志物。 它已被证明是一种活性金属蛋白酶，可能参与细胞迁移、细胞粘附、细胞-细胞和细胞-基质相互作用以及信号转导等正常生理过程。 它被提议在病理过程中发挥作用，例如癌症、炎症性疾病、肾脏疾病和阿尔茨海默氏病。 [RefSeq 提供，2013 年 5 月] This gene encodes a member of the ADAM …

ADAM19 plays essential roles in embryo implantation, cardiovascular morphogenesis, neurogenesis, and other developmental processes. It has constitutive alpha-secretase activity associated with processing Alzheimer's disease amyloid precursor protein (APP) to non-amyloidogenic fragments; thus, it is neuroprotective.

Progressive atrioventricular conduction block in a mouse myotonic dystrophy model. 这个基因编码一个细胞表面糖蛋白，并属于ADAM（整合素和金属蛋白酶）家族的内肽酶成员。 编码的蛋白质可能在神经调节蛋白的胞外域脱落中起作用。 这个基因的纯合子敲除小鼠表现出心脏发育缺陷和围产期致死。 可变剪接导致多个转录子变异体，至少其中一个编码前原蛋白质，该前原蛋白质经历蛋白水解处理以生成成熟的蛋白质产物。 [由RefSeq，2015年8月提供]

To determine the potential novel role of ADAM19 in the metabolic syndrome, we first conducted microarray studies on peripheral blood mononuclear cells from a well-characterised human cohort. Secondly, we examined the expression of ADAM19 in liver and gonadal white adipose tissue using an in vivo diet induced obesity mouse model.

这个基因编码ADAM（整合素和金属蛋白酶结构域）家族的一员。 这个家族的成员是结构上与蛇毒整合素有关的膜锚定蛋白，并与涉及细胞间和细胞基质相互作用的各种生物过程有关，包括受精、肌肉发育和神经发生。 这个成员是一个I型跨膜蛋白，作为树突状细胞分化的标志。 已经证明它是一个活跃的金属蛋白酶，可能参与正常的生理过程，如细胞迁移、细胞粘附、细胞间和细胞基质相互作用以及信号传导。 据推测，它在癌症、炎症性疾病、肾脏疾病和阿尔茨海默病等病理过 …

2020年11月23日 · Title: Human umbilical cord mesenchymal stem cell-derived exosomal miR-335-5p attenuates the inflammation and tubular epithelial-myofibroblast transdifferentiation of renal tubular epithelial cells by reducing ADAM19 protein levels.