抗癌新靶标之ADAM9—ADC、单抗、小分子抑制剂研究 - 知乎
ADAM9（A distegrinin and a metalloprotease 9）是一种膜锚定蛋白，主要通过用于粘附的分解蛋白结构域和用于脱落多种细胞表面蛋白的 金属蛋白结构域 参与多种生理功能。 近年越来越多 …
An Overview of ADAM9: Structure, Activation, and Regulation in …
ADAM9-S is a secreted protein, lacking the transmembrane and cytoplasmic domains via excising exon 12 from the ADAM9 mRNA, and contains 8 unique amino acids (LSLKFHAPF) not …
A pan-cancer study of ADAM9’s immunological function and
2024年11月6日 · Immunohistochemistry (IHC) staining from 90 pathologically verified samples proved the positive correlation between ADAM9 and tumor stages and proved the higher …
An Overview of ADAM9: Structure, Activation, and Regulation in …
2020年10月21日 · ADAM9 (A disintegrin and a metalloprotease 9) is a membrane-anchored protein that participates in a variety of physiological functions, primarily through the disintegrin …
ADAM9在实体肿瘤生物学中的相关研究进展 - 汉斯出版社
肿瘤组织中adam9表达明显高于正常胃组织，体外应用抗adam9抗体抑制胃癌细胞的生长，提示adam9通过信号分子的脱落或与粘附分子的相互作用在细胞增殖中发挥作用，在表达最高水 …
An Overview of ADAM9: Structure, Activation, and Regulation in …
2020年10月21日 · ADAM9-S is a secreted protein, lacking the transmembrane and cytoplasmic domains via excising exon 12 from the ADAM9 mRNA, and contains 8 unique amino acids …
被AbbVie放弃的ADAM9 ADC，抗癌效力究竟几何？ - 百家号
2024年7月25日 · ADAM9-S是一种分泌蛋白，通过切除ADAM9 mRNA中的外显子12而缺乏跨膜和胞质结构域，并含有8个ADAM9-L中不存在的独特氨基酸 (LSLKFHAPF)。 ADAM9作为蛋白 …
ADAM9 Gene - GeneCards | ADAM9 Protein | ADAM9 Antibody
2024年12月24日 · ADAM9 (ADAM Metallopeptidase Domain 9) is a Protein Coding gene. Diseases associated with ADAM9 include Cone-Rod Dystrophy 9 and Cone-Rod Dystrophy 2. …
被AbbVie放弃的ADAM9 ADC，抗癌效力究竟几何？ - 专注肿瘤免疫
2024年7月30日 · ADAM9-S是一种分泌蛋白，通过切除ADAM9 mRNA中的外显子12而缺乏跨膜和胞质结构域，并含有8个ADAM9-L中不存在的独特氨基酸 (LSLKFHAPF)。 ADAM9作为蛋白 …
Structure, regulatory factors and cancer-related physiological …
In studies on breast cancer, ADAM9-S was found to positively promote tumor cell migration, in contrast to ADAM9-L, which greatly diminished this effect or inhibited tumor migration. …
抗癌新靶标ADAM9有何过人之处 - 知乎 - 知乎专栏
2023年2月2日 · IMGC936 是由ImmunoGen与Macrogenics合作开发的首款靶向ADAM9的新型 ADC，用于治疗非小细胞肺癌，胃癌，胰腺癌，三阴性乳腺癌和结直肠癌等实体瘤。 在2021 …
Deciphering the oncogenic potential of ADAM9 in hepatocellular ...
2024年11月2日 · Our results demonstrate that high ADAM9 expression is associated with poor prognosis and increased immune infiltration in HCC patients. Furthermore, ADAM9 …
ADAM9 promotes type I interferon-mediated innate immunity
2024年5月16日 · ADAM9 is implicated in a range of human diseases, including inflammatory diseases; however, its role in viral infection is unknown. Here, we demonstrate that mice …
Structure, regulatory factors and cancer-related physiological effects ...
The ADAMs family belongs to the transmembrane protein superfamily of zinc-dependent metalloproteases, which consists of multiple domains. These domains have independent but …
Full article: Structure, regulatory factors and cancer-related ...
2020年9月12日 · In studies on breast cancer, ADAM9-S was found to positively promote tumor cell migration, in contrast to ADAM9-L, which greatly diminished this effect or inhibited tumor …
抗癌新靶标之ADAM9—ADC、单抗、小分子抑制剂研究医药新闻-B…
ADAM9（A distegrinin and a metalloprotease 9）是一种膜锚定蛋白，主要通过用于粘附的分解蛋白结构域和用于脱落多种细胞表面蛋白的金属蛋白结构域参与多种生理功能。 近年越来越多 …
抗癌新靶标ADAM9有何过人之处 - 新浪财经
2023年1月31日 · IMGC936是由ImmunoGen与Macrogenics合作开发的首款靶向ADAM9的新型 ADC，用于治疗非小细胞肺癌，胃癌，胰腺癌，三阴性乳腺癌和结直肠癌等实体瘤。 在2021 …
Inhibition of ADAM9 promotes the selective degradation of KRAS …
2024年1月24日 · Suppression of ADAM9 by a small-molecule inhibitor restricts disease progression in spontaneous models, and combination with gemcitabine elicits dramatic …
An Overview of ADAM9: Structure, Activation, and
2020年10月21日 · ADAM9 (A disintegrin and a metalloprotease 9) is a membrane-anchored protein that participates in a variety of physiological functions, primarily through the disintegrin...
ADAM9 functions as a transcriptional regulator to drive angiogenesis …
2021年9月7日 · Hypoxia and angiogenesis play key roles in the pathogenesis of esophageal squamous cell carcinoma (ESCC), but regulators linking these two pathways to drive tumor …
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