2024年12月24日 · ADAMTS2 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 2) is a Protein Coding gene. Diseases associated with ADAMTS2 include Ehlers-Danlos Syndrome, Dermatosparaxis Type and Overlapping Connective Tissue Disease. Among its related pathways are O-linked glycosylation of mucins and Collagen chain trimerization.

A disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAM-TS2) also known as procollagen I N-proteinase (PC I-NP) is an enzyme [4] that in humans is encoded by the ADAMTS2 gene. [5][6] The ADAMTS2 gene is located on the long (q) arm of chromosome 5 at the end (terminus) of the arm, from base pair 178,473,473 to base pair 178,704,934.

The ADAMTS2 gene provides instructions for making an enzyme that processes several types of procollagen molecules. Procollagens are the precursors of collagens, which are complex molecules found in the spaces between cells that add strength, support, and stretchiness (elasticity) to many body tissues.

ADAM (A Disintegrin and Metallo-proteinases)和ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) 是基质锌依赖的金属蛋白酶，它们一起被称为 adamalysins。 ADAM 金属蛋白酶是跨膜和分泌蛋白，而 ADAMTS 是分泌形式。 Adamalysins 主要存在于细胞外基质 (ECM) 中，它们可以通过间隔域 (SD) 或血小板结合蛋白基序 (TS) 与细胞外基质连接。 所有的adamalysins 最初都是作为前体合成的，其中大部分可以被 furin 激活。 它们通过信号通路、细 …

2024年12月10日 · Go to complete Gene record for ADAMTS2; Go to Variation Viewer for ADAMTS2 variants; Summary. This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family.

Data indicate that ADAMTS2 and 3 cleave the amino-propeptide of fibrillar collagens and regulate blood vessels homeostasis and lymphangiogenesis. Also, ADAMTS2 deficiency leads to the dermatosparactic type of Ehlers-Danlos syndrome.

Collectively, we propose that ADAMTS2 regulates the hypertrophic response through inhibiting the activation of the PI3K/AKT-dependent signaling pathway. Because ADAMTS2 is an extracellular protein, it could be effectively manipulated using pharmacological means to modulate cardiac hypertrophy.

2015年5月1日 · ADAMTS2, 3 and 14 cleave the amino-propeptide of fibrillar collagens. ADAMTS2 deficiency leads to the dermatosparactic type of Ehlers–Danlos syndrome. ADAMTS2 and 3 are regulators of blood vessels homeostasis and lymphangiogenesis. Larger repertoire of substrates and functions are likely for these ADAMTS.

ADAM TS-2的激活涉及多种剪切过程,包括前体蛋白转化酶 ( pro -protein convertases)和C -末端剪切,会产生7种不同的剪切产物,其中104kD氨基末端剪切产物活性最高。

这个基因编码ADAMTS（整合素和金属蛋白酶与血栓素模序）蛋白家族的成员。 这个家族的成员共享几个独特的蛋白质模块，包括前肽区域、金属蛋白酶结构域、整合素样结构域和血栓素类型1（TS）模序。 这个家族的个别成员在C端TS模序的数量上有所不同，有些还具有独特的C端结构域。 编码的前原蛋白在蛋白水解过程中被加工成成熟的原胶原蛋白N-蛋白酶。 这种蛋白酶切除原胶原蛋白I-III型和V型的N端肽。 这个基因的突变导致Ehlers-Danlos综合症类型VIIC，这是一 …