2020年12月15日 · Mesenchymal stem cell (MSC)-based therapy has emerged as a novel strategy to treat many degenerative diseases. Accumulating evidence shows that the function of MSCs …

2021年9月1日 · Here, we review age-related alterations of MSCs in musculoskeletal tissues, and address the underlying mechanisms of aging and senescence of MSCs. Furthermore, we …

2023年7月18日 · Ageing of stem cells (SCs) is involved in age-related diseases. MSCs are endowed with a potent immune suppression capacity in the inflammatory environment due to …

2024年11月17日 · It is well recognized that MSCs in vitro acquire culture-induced aging features such as gradual telomere shortening, increased numbers of senescent cells, and reduced …

In this review, we will concisely discuss current progress on the detailed mechanisms of MSC senescence and various inflicted changes following aging in MSC. We will also shed light on …

2024年5月10日 · Adult mesenchymal stem cells (MSCs) look like fibroblasts and can self-renew and specialize into osteoblasts, adipocytes, and chondrocytes. In early development, they …

2023年7月20日 · Our results demonstrate that MSCs undergo a progressive aging process and that the cellular senescence state influences their immunosuppressive activity by …

2014年1月7日 · Aged MSCs displayed senescent features when compared with cells isolated from young donors, concomitant with reduced viability and proliferation. These features were …

2025年3月19日 · Taken together, these findings indicate that UC-MSCs may have potential therapeutic benefits for age-related changes seen within these important immune organs, and …

2025年2月21日 · In the past, cell therapy involving the direct transplantation of mesenchymal stem cells (MSCs) has made significant progress in combating aging-related conditions, …