The Argonaute (AGO) gene family encodes six characteristic domains: N- terminal (N), Linker-1 (L1), PAZ, Linker-2 (L2), Mid, and a C-terminal PIWI domain. [8]

Jul 30, 2024 · Argonaute 2蛋白 （AGO2），亦称 真核翻译起始因子2C2 ( eukaryotic translation initiation factor 2C subunit 2，EIF2C2) 。含有N末端( amino-terminal) 、PAZ、MID 和PIWI 四 …

Dec 24, 2024 · AGO2 (Argonaute RISC Catalytic Component 2) is a Protein Coding gene. Diseases associated with AGO2 include Lessel-Kreienkamp Syndrome and Non-Specific …

Oct 16, 2023 · AGO2（Argonaute 2）蛋白是RNA干扰（RNAi）和微小RNA（miRNA）通路中的一种关键因子，具有重要的生物学功能。 具体来说，AGO2蛋白可与小RNA（如siRNA …

Nov 16, 2020 · We identify 13 heterozygous mutations in AGO2 in 21 patients affected by disturbances in neurological development. Each of the identified single amino acid mutations …

Ago2也是四种Ago蛋白中表达量最高的一种，诸多实验证明，Ago2就是Slicer酶，活性依赖于二价金属阳离子。 所有四种人类Ago的效应复合物都会引起翻译抑制和mRNA降解。

The human Argonaute2 protein (Ago2) is a key player in RNA interference pathway and small RNA recognition by Ago2 is the crucial step in siRNA mediated gene silencing mechanism. …

Nov 19, 2020 · Argonaute (AGO) 蛋白是 RNA 介导的转录后基因调控的关键蛋白，为 miRNA 提供锚位点，形成 RNA 诱导沉默复合体 RISC 达到降解靶基因或者抑制翻译的目的。 自 1993 年 …

Argonaute2蛋白 （AGO2）通过参与构成 RNA诱导的沉默复合体,其自身催化及自身过表达功能,在人类肿瘤的发生发展中扮演了重要角色,逐渐成为研究焦点。 Ago2表达水平变化或功能失调 …

AGO2 is the only member with catalytic activity in Argonaute family and contains four functional core domains, which are N domain, PAZ domain, MID domain, and PIWI domain from N …

Jun 11, 2021 · Argonaute 2 (AGO2) is an indispensable component of the RNA-induced silencing complex, operating at the translational or posttranscriptional level. It is compartmentalized into …

Feb 20, 2025 · AGO2 Mediates MYC mRNA Stability in Hepatocellular Carcinoma. Human Argonaute2 and Argonaute3 are catalytically activated by different lengths of guide RNA. …

Mohamed et al. report the cryoelectron microscopy structure of human AGO2 with fully paired guide RNA. Their analysis reveals the structural basis for the slicing activity that drives RNAi, …

Aug 15, 2023 · Argonaute 2 (Ago2) is a key component of the RNA interference (RNAi) pathway, a gene-regulatory system that is present in most eukaryotes. Ago2 uses microRNAs (miRNAs) …

近日，Whitehead研究所 David P. Bartel 研究组在 Science 发表文章 The biochemical basis of microRNA targeting efficacy，对RNA bind-n-seq（RBNS）测序进行优化，用于 测量miRNA …

Jul 31, 2024 · Argonaute 2蛋白（AGO2），亦称真核翻译起始因子2C2 ( eukaryotic translation initiation factor 2C subunit 2，EIF2C2) 。 含有N末端( amino-terminal) 、PAZ、MID 和PIWI 四 …

Mar 13, 2020 · In traditional view, AGO2 serves as the catalytic engine of the RNA induced silencing complex and plays an important role in small RNAs guided post transcriptional gene …

Argonaute 2 (Ago2) is a key component of the RNA interference (RNAi) pathway, a gene-regulatory system that is present in most eukaryotes. Ago2 uses microRNAs (miRNAs) and …

Jul 31, 2024 · Argonaute 2蛋白（AGO2），亦称真核翻译起始因子2C2 ( eukaryotic translation initiation factor 2C subunit 2，EIF2C2) 。 含有N末端( amino-terminal) 、PAZ、MID 和PIWI 四 …

We identify 13 heterozygous mutations in AGO2 in 21 patients affected by disturbances in neurological development. Each of the identified single amino acid mutations result in impaired …