2023年9月5日 · Aha1 (activator of Hsp90 ATPase) is the only known co-chaperone that significantly accelerates the ATPase activity of Hsp90 and by this enhances its function (14). It contributes to the activation of several client proteins such as protein kinases and steroid hormone receptors (8, 14).

2004年2月15日 · We find that loss of function in aha-1 causes morphological defects in RMEL/R neurons identical to those in ahr-1mutants, and that the ectopic effect of ahr-1 requires aha-1. An independent study has found that several ahr-1 expressing neurons exhibit aberrant cell morphology and cell migration defects in ahr-1 mutants (H. Qin and J.A.P.-C ...

By binding to a cis-regulatory element in the cam-1 promoter, AHA-1 enhances cam-1 transcription. Our study reveals a Wnt-dependent fine-tuning mechanism that is crucial for mutual target cell identification during the formation of gap junction connections.

AHA-1抗体（F-7）是一种IgG1 κ小鼠单克隆AHA-1抗体（也称为AHA-1抗体），可通过WB、IP、IF和ELISA检测小鼠、大鼠和人源的AHA-1蛋白。 AHA-1抗体（F-7）既可作为非偶联抗AHA-1抗体形式提供，也可作为多种偶联形式的抗AHA-1抗体提供，包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。 AHA-1能刺激酵母和人类HSP 90的固有ATPase活性，并与囊泡性口炎病毒糖蛋白的细胞质尾部相互作用。 AHA-1通过影响"ATP盖"的构象状态和随后的N端二聚化来调 …

2015年5月1日 · Aha1 was found to be associated with several proteins involved in RNA processing and transport (Table 1): C1QBP/p32 [70], DDX47 [71], and PDCD11/RRP5 [72], are all involved in the proper processing of pre-rRNA and the assembly of pre-40S and -60S ribosomal subunits; SF3B1 (Fig. 1 C), DDX46 and hnRNPH1 are …

2016年9月12日 · Using ATPase assays with Hsp90 heterodimers, we find that Aha1p stimulates ATPase activity by a three-step mechanism via the catalytic loop in the middle domain of Hsp90. Binding of the Aha1p N...

Aha1 (activator of Hsp90 ATPase) stimulates the ATPase activity of the molecular chaperone Hsp90 to accelerate the conformational cycle during which client proteins attain their final shape. Thereby, Aha1 promotes effective folding of Hsp90-dependent clients such as steroid receptors and many kinases involved in cellular signaling.

Aryl hydrocarbon receptor nuclear translocator homolog. aha-1 and ahr-1 act genetically upstream of cam-1. CAM-1, a membrane-bound receptor tyrosine kinase, is present on both BDU and PLM cells and likely serves as a Wnt antagonist.

AHA-1 活化剂包括 Radicicol CAS 12772-57-5、氧化砷（III）CAS 1327-53-3、MG-132 [Z-Leu- Leu-Leu-CHO] CAS 133407-82-6 和过氧化氢 CAS 7722-84-1。

2021年3月30日 · Aha1 is the only co-chaperone known to strongly stimulate the ATPase activity of Hsp90. Meanwhile, besides the well-studied co-chaperone function, human Aha1 has also been demonstrated to exhibit chaperoning activity against stress-denatured proteins.