Adenosylhomocysteinase (AHCY) is a unique enzyme and one of the most conserved proteins in living organisms. AHCY catalyzes the reversible break of S -adenosylhomocysteine (SAH), the by-product and a potent inhibitor of methyltransferases activity. In mammals, AHCY is the only enzyme capable of performing this reaction.

2024年12月24日 · AHCY (Adenosylhomocysteinase) is a Protein Coding gene. Diseases associated with AHCY include Hypermethioninemia With S-Adenosylhomocysteine Hydrolase Deficiency and S-Adenosylhomocysteine Hydrolase Deficiency. Among its related pathways are methionine degradation and Peptide chain elongation.

2021年6月7日 · 在高等生物中腺苷高半胱氨酸酶AHCY ( adenosylhomocysteinase) 是唯一分解SAH的酶，因此抑制 AHCY的酶活导致细胞内SAH的积累，进而抑制甲基转移反应，AHCY的抑制剂ADOX ( adenosine dialdehyde) 常常作为甲基转移酶的间接抑制剂使用[2]。 2017年，一篇研究发现BMT2/SAMTOR能够感知细胞内SAM的浓度，调控MTOR信号通路，在胞内缺乏SAM的时候，BMT2抑制MTOR的活性[3]。 自噬是MTOR信号通路调控的主要生物学过程之一，也是细胞 …

2024年5月29日 · AHCY is the gene that encodes the enzyme adenosylhomocysteinase. In mammals, AHCY is the only enzyme that can convert SAH to homocysteine, and it can also catalyze the reverse conversion of homocysteine to SAH.

它催化 S-腺苷高半胱氨酸 (AdoHcy) 可逆水解为腺苷 (Ado) 和 L-高半胱氨酸 (Hcy) 。 因此，它调节细胞内 S-腺苷高半胱氨酸 (SAH) 浓度，该浓度被认为对转甲基反应很重要。 这种蛋白质的缺乏是高甲硫氨酸血症的不同原因之一。 已发现该基因编码不同亚型的可变剪接转录物变体。 [RefSeq 提供，2009 年 6 月] S-adenosylhomocysteine hydrolase belongs to …

2020年4月23日 · 腺苷同型半胱氨酸水解酶（ Adenosylhomocysteinase, AHCY ）是甲硫氨酸代谢途径中重要的代谢酶，它催化 硫代 腺苷同型半胱氨酸（ S-adenosylhomocysteine, SAH ）水解产生腺苷（ adenine ）和同型半胱氨酸（ homocysteine ）。

2021年3月31日 · Adenosylhomocysteinase (AHCY) is a unique enzyme and one of the most conserved proteins in living organisms. AHCY catalyzes the reversible break of S...

由于SAM和SAH都不能自由穿越细胞膜，通过SAM合酶的抑制剂cLEU和AHCY的抑制剂ADOX分别降低胞内SAM的浓度和积累SAH。 和之前的报道一致，减少SAM能够通过抑制MTOR激活自噬，而高浓度的SAH能够抑制自噬却不改变MTOR的活性。 敲低AHCY也能够抑制细胞自噬。...

S-Adenosylhomocysteine hydrolase (AHCY) is the only mammalian enzyme known to catalyze the hydrolysis of S-adenosylhomocysteine. We have used a genotype-to-phenotype strategy to study this important enzyme by resequencing AHCY in 240 DNA samples from four ethnic groups.

2021年3月30日 · Adenosylhomocysteinase (AHCY) is a unique enzyme and one of the most conserved proteins in living organisms. AHCY catalyzes the reversible break of S -adenosylhomocysteine (SAH), the by-product and a potent inhibitor of methyltransferases activity. In mammals, AHCY is the only enzyme capable of performing this reaction.