Depletion of USP21 does not affect the DNA-binding ability of AIM2 but inhibits the formation of the AIM2–ASC complex. Our findings establish that fine-tuning of AIM2 by the ubiquitin system is important for regulating AIM2 inflammasome activation.

2019年3月4日 · In the present study, we found that luteolin significantly reduced the expression of absent in melanoma 2 (AIM2) at both mRNA and protein levels leading to the suppression of AIM2 inflammasome...

2021年10月1日 · Upon DNA stimulation, USP21 binds to AIM2 and deubiquitinates it, thereby increasing its protein stability. In addition to the role of USP21 in regulating AIM2 turnover, we uncovered that USP21-mediated deubiquitination of AIM2 is required for the assembly of the AIM2 inflammasome.

Activation of the AIM2 inflammasome resulted in the accumulation of p21 through the inhibition of its proteasomal degradation, thereby facilitating the myeloid differentiation. Importantly, the combined therapy dramatically reduced the total leukemia cell counts and proportion of blast cells in the spleens of AML mice.

2024年11月12日 · Absent in melanoma 2 (AIM2) serves as an intracellular nucleic acid sensor that predominantly detects double-stranded DNA (dsDNA) within the cells. This detection initiates the assembly of inflammasome and activates the inflammasome signaling cascade, resulting in the production of inflammatory mediators and the cleavage of Gasdermins.

The discovery of critical interactions among NLRP3, AIM2, NLRC4, and Pyrin represents a new paradigm in understanding the functions of these molecules in innate immunity and inflammasome biology as well as identifying new therapeutic targets for NLRP3-, AIM2-, NLRC4- and Pyrinmediated diseases.

2025年1月16日 · P21基因，又称CDKN1A（cyclin-dependent kinase inhibitor 1A），是定位于人类基因组上的一个关键基因。 它编码的蛋白质p21是一种细胞周期素依赖性激酶抑制因子，属于Clp（CIP/KIP）家族的一员。

黑素瘤缺乏因子2（简称AIM2）是干扰素诱导的HIN-200蛋白家族中的一员，可与细胞质中双链DNA结合，并与ASC和Caspase-1组装激活AIM2炎性小体，从而使生物活性白介素-β1（IL-β1）和IL-18的分泌，并诱导细胞焦亡。

AIM2可与细胞质中的双链DNA结合，激活AIM2炎性小体，进而促进生物活性白介素-β1（IL-β1）和IL-18的分泌，并诱导细胞焦亡。 此外，AIM2还在调节免疫细胞功能，特别是Treg细胞和B细胞分化中扮演重要角色，对自身免疫性疾病如系统性红斑狼疮（SLE）的发病机制和治疗靶点有重要意义。 这些发现揭示了AIM2在生物学和医学领域的广泛应用前景。

黑色素瘤缺乏因子2 (AIM2)炎症小体作为其中的调控蛋白之一,能够识别细胞损伤、病原微生物感染等引起DNA损伤的信号,在固有免疫应答中发挥着重要作用。