The versatile Akapp-Stemmann 7-pole conductor bar system. Compact, reliable and secure power supply system for cranes, hoists, trolleys, automated warehouses, etc. Worldwide installations applied both inside and outside, high and low temperatures and under extreme (weather) conditions.

conductor bar system is used to supply power to numerous cranes and hoists all over the world. The basic design of AKAPP 4-Ductor is a channel housing, in which 4 copper conduc-tors can be pulled. The flat conductors are installed without joints ensuring a trouble free operation. 4-Ductor provides all the advantages that are part of the unique

1999年6月1日 · Neutron and x-ray scattering experiments have defined the quaternary structure of the PKA holoenzyme as an extended antiparallel dumbbell, where the bar is formed by the R subunit dimerization domains, and the bells represent the interaction between the R …

2024年3月20日 · Using whole cell patch clamp recordings in LHb of male wildtype and ΔPKA knockin mice (with deficiency in AKAP-anchoring of PKA), here we show that the genetic disruption of PKA anchoring to...

Disrupting PKA anchoring to AKAPs increased the cAMP gradient in early-stage neurons and led to enhanced axon elongation. Our results provide new evidence for a local negative feedback loop, assembled by AKAPs, for the precise control of a growth-stage-dependent cAMP gradient to ensure proper axon growth.

A型激酶锚定蛋白 (A-kinase anchoring proteins，AKAPs)是一类结构不同而功能相关的蛋白家族，其主要功能是将cAMP依赖性蛋白激酶A（PKA）锚定于特定的亚细胞结构.PKA是第二信使cAMP的主要效应器，而AKAPs在靶向定位和调节PKA介导的磷酸化事件方面扮演重要角色....

2023年12月6日 · Numerous studies of hippocampal synaptic function in learning and memory have established the functional significance of the scaffolding A-kinase anchoring protein 150 (AKAP150) in kinase and phosphatase regulation of synaptic receptor and ion channel trafficking/function and hence synaptic transmission/plasticity, and neuronal excitability.

2020年7月7日 · Dual-specificity protein kinase A anchoring protein 1 (dAKAP1) is a multivalent binding protein that targets protein kinase A (PKA), RNAs, and other signaling enzymes to the outer mitochondrial membrane. Many AKAPs recruit a diverse set of binding partners that coordinate a broad range of cellular processes.

2015年4月15日 · In the present study, we tested the role of AKAPs in CSE-induced IL-8 release from ASM cells and assessed the effect of CSE on the expression levels of different AKAPs. We also studied mRNA and protein expression of AKAPs in lung tissue from patients with COPD.

2022年1月1日 · AKAP-PKA interactions play a role in a variety of cellular processes including β-adrenoceptor-dependent regulation of cardiac myocyte contraction or vasopressin-mediated water reabsorption. The tethering of PKA through AKAPs by itself is not sufficient to compartmentalize and control a cAMP/PKA-dependent pathway.