The A-kinase anchoring proteins or A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. [1][2] At least 20 AKAPs have been cloned. [3] .

2004年12月1日 · Here, we discuss two emerging principles in AKAP signalling: the combinatorial assembly of different enzymes on the same AKAP backbone; and the dynamic reorganization of AKAP complexes. cAMP...

A型激酶锚定蛋白 (A-kinase anchoring proteins，AKAPs)是一类结构不同而功能相关的蛋白家族，其主要功能是将cAMP依赖性蛋白激酶A（PKA）锚定于特定的亚细胞结构.PKA是第二信使cAMP的主要效应器，而AKAPs在靶向定位和调节PKA介导的磷酸化事件方面扮演重要角色....

1999年6月1日 · The four helices of the RIIα (1–45) dimer are indicated in blue. The upper two helices are predicted to form contacts with the AKAP; the lower two mediate dimerization. The backbone ribbon of the AKAP (Ht31) peptide, shown in yellow, has been modelled to fit into its putative binding site on RII.

2022年1月1日 · A-kinase anchoring protein (AKAP) interaction with cAMP-dependent protein kinase (PKA). The unifying characteristic of canonical AKAPs is the presence of a structurally conserved amphipathic binding helix (orange) which binds in a hydrophobic cleft created by the docking and dimerization (D/D) domains of the regulatory (R) subunits of PKA.

激酶锚定蛋白 (akap) 是一组结构多样的蛋白质，它们具有与蛋白激酶 a 的调节亚基结合并将全酶限制在细胞内离散位置的共同功能。该基因编码 akap 家族的一个成员。

Here, we review mechanisms that bestow protein kinase A (PKA) versatility inside the cell, appraise recent advances in exploiting AKAPs as platforms for precision pharmacology, and explore the impact of methodological innovations on AKAP research.

AKAPs localize, specify, amplify and accelerate signal transduction within the cell by bringing signaling proteins together in space and time. AKAPs also organize higher-order network motifs such as feedforward and feedback loops that may create complex network responses including adaptation, oscillation, and ultrasensitivity.

A-kinase anchoring protein (AKAP) 12 is a scaffolding protein that anchors various signaling proteins to the plasma membrane. These signaling proteins include protein kinase A, protein kinase C, protein phosphatase 2B, Src-family kinases, cyclins, and calmodulin, which regulate their respective sign …

AKAPs are a diverse group of molecules that function as cell signaling scaffolds. Specifically, AKAPs dynamically organize and juxtapose protein kinase A (PKA) with specific substrates and other signaling machinery at specific cellular locales.