There is increasing recognition that acute kidney injury (AKI) and chronic kidney disease (CKD) are closely linked and likely promote one another. Underlying CKD is now recognized as a clear risk factor for AKI, as both decreased glomerular filtration rate (GFR) and increased proteinuria have each been shown to be strongly associated with AKI.

In this review we will discuss functions of the kidney implicated in AKI and CKD, and examine the clinical and experimental evidence for their role in determining levels of acute renal injury and adaptive vs maladaptive renal repair.

Acute kidney injury (AKI) and chronic kidney disease (CKD) are inter-connected. While AKI-to-CKD transition has been intensively studied, the information of AKI on CKD is very limited. Nonetheless, AKI, when occurring in CKD patients, is known to …

2019年12月1日 · Acute kidney injury is a clinical syndrome characterized by a rapid decline in glomerular filtration rate and resultant accumulation of metabolic waste products. Acute...

2024年4月8日 · Acute kidney injury (AKI) An acute kidney injury (AKI) is caused by a rapid deterioration in kidney function. The pathophysiology of AKI is separated into three main causes: Pre-renal: decreased blood supply resulting in decreased GFR; Renal: damage to the nephron impairing the reabsorption capacity

2015年8月6日 · 改善全球肾脏病预后组织（kdigo)发布的该指南，指出了aki的诊断、预防、药物治疗、肾脏替代治疗等方面的建议，对临床工作具有积极指导意义。 丁香无线

2.1.1 急性肾损伤（Acute Kidney Injury, AKI）的定义是出现以下情况的任意一种（未分级）： 48小时内SCr升高 ≥ 26.5!mol/L；或 已知或认定在过去7天内SCr升高 ≥ 基线值的1.5倍；或

2017年12月29日 · Acute Kidney Injury (AKI) is a frequent disorder with an incidence of 400 per 100′000 persons per year in community-based populations [1]. AKI has been associated with increased mortality and progression to CKI [2], and there is increased awareness of its ominous long-term prognosis [3].

2015年12月15日 · 2014 年，急性透析质量倡议（ADQI）提出急性肾损伤（AKI）的 RIFLE 诊断标准，分为肾损伤危险、肾损伤、肾衰竭、肾功能丧失、终末期肾衰竭。 此后该标准重新定义为 3 期。 2012 年 KDIGO 临床实践指南对此进行了修正。 目前的 AKI 定义及分类只包含了功能变化：血肌酐和尿量的变化，而 CKD 的定义包括了结构（蛋白尿）和功能（eGFR）的变化这两项。 既定的 AKI、CKD 的定义和分类广泛应用于临床工作、研究和公共健康，促进了临床医师对肾脏 …

急性肾损伤（Acute kidney injury, AKI）是临床常见的急危重症，不仅会引起严重的急性机体内环境紊乱而威胁患者生命，研究还发现，AKI进展为慢性肾脏病（CKD）的风险显著增加，是CKD形成和终末期肾病发生的重要原因，由于其确切诱发机制尚不清楚，因而成为肾脏 ...