Acute kidney injury (AKI) is a common, serious complication of cardiac surgery. Since prior studies have supported a genetic basis for postoperative AKI, we conducted a genome-wide association study (GWAS) for AKI following coronary bypass graft (CABG) surgery.

This review attempts to address the role of key genes in the appearance and development of AKI, providing not only a comprehensive update of the intertwined process involved but also identifying specific markers that could serve as precise targets for further AKI therapies.

2023年7月1日 · AKI is a heterogeneous clinical syndrome with various underlying risk factors, etiologies, and pathophysiology that may limit the identification of genetic variants. Although no variants reached genome-wide significance, we report two variants in the intergenic region between <i>DISP1</i> and <i>TLR</i> …

2023年6月5日 · We identified the precise cell types that express candidate genes associated with AKI in ASSESS-AKI and the degree to which these genes were differentially expressed in AKI using a single-cell Ribonucleic acid sequencing (RNAseq) dataset from AKI biopsy tissue obtained through the Kidney Precision Medicine Project (KPMP). 19 Some of the results ...

2024年8月1日 · Prior GWASs of AKI have been underpowered because of limited sample size, and significant “hits” have not been reproducible. Although GWASs, exome sequencing, and whole-genome sequencing all can identify a genetic basis for a phenotype outcome, GWAS is more scalable at lower cost and surveys common genetic variation.

2024年8月1日 · We sought to identify genetic loci associated with AKI among patients with hospitalized AKI. We conducted a large GWAS meta-analysis of persistent AKI among participants of the Million Veteran Program 23 and Vanderbilt University Medical Center’s DNA biobank (BioVU).

Genome wide association studies (GWAS) employ an unbiased approach to identify candidate SNPs in all the genes that may be associated with a given disease state. DNA obtained from blood or buccal smears from patients and control subjects is scanned using commercially available array chips that now routinely contain well over 1 million SNPs.

本研究通过全基因组关联研究（GWAS）分析了AKI与脓毒症之间的遗传关联，并运用了LASSO、SVM-RFE和RF三种不同的机器学习算法，严格识别和验证了SA-AKI的特征基因。

2024年12月5日 · We hypothesize that the genetic pathway behind S-AKI has overlapping mechanisms with key differences based upon the specific subtype of acute kidney injury (AKI). To test this hypothesis, we performed a genome-wide association study (GWAS) of S-AKI in three logistic regression models.

Acute kidney injury (AKI) is a common, serious complication of cardiac surgery. Since prior studies have supported a genetic basis for postoperative AKI, we conducted a genome-wide association study (GWAS) for AKI following coronary bypass graft (CABG) surgery.