2024年12月24日 · AKR1C2 (Aldo-Keto Reductase Family 1 Member C2) is a Protein Coding gene. Diseases associated with AKR1C2 include 46,Xy Sex Reversal 8 and Cic-Rearranged Sarcoma. Among its related pathways are Bile acid and bile salt metabolism and Metabolism.

Aldo-keto reductases, including AKR1C2, are NAD(P)H-linked oxidoreductases that primarily catalyze the reduction of aldehydes and ketones to primary and secondary alcohols. This reduction is dependent on NADPH.

研究表明AKR1C2参与调节肿瘤侵袭、迁移等恶性表型，消除活性氧（ROS），促进肿瘤细胞化疗耐药，在某些癌症中具有预后价值。 在这里，我们重点讨论AKR1C2在不同类型肿瘤中的作用和临床意义。 Function, drug resistance and prognostic effect of AKR1C2 in human cancer.

AKR1C2, is also known as bile-acid binding protein and DD2, has lower catalytic efficiencies but preferentially reduces 3-ketosteroids. AKR1C2 preferentially reduces DHT to the weak metabolite 5α-androstane-3α,17β-diol (3α-diol) without conversion of 3α-diol to DHT in …

AKR1C2 acts as a targetable oncogene in esophageal squamous cell carcinoma via activating PI3K/AKT signaling pathway. Ligand entry in human ileal bile acid-binding protein is mediated by histidine protonation. Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis.

Studies have shown that AKR1C2 is involved in regulating tumor invasion, migration, and other malignant phenotypes, eliminating reactive oxygen species (ROS), promoting chemotherapy resistance of tumor cells, and has prognostic value in some cancers. Here, we focus on the role and clinical significance of AKR1C2 in different types of tumors.

该基因编码醛/酮还原酶超家族的一个成员，该家族由 40 多种已知的酶和蛋白质组成。 这些酶使用 NADH 和/或 NADPH 作为辅因子催化醛和酮转化为其相应的醇。 这些酶显示重叠但不同的底物特异性。 该酶以高亲和力结合胆汁酸，并显示出最小的 3-α-羟基类固醇脱氢酶活性。 该基因与其他三个基因成员具有高度序列同一性，并与染色体 10p15-p14 上的这三个基因聚集在一起。 已发现该基因编码两种不同亚型的三种转录变体。 [RefSeq 提供，2011 年 12 月]

2023年9月7日 · 醛酮还原酶1C2 (AKR1C2)是一种依赖还原型辅酶Ⅱ (NADPH)将醛和酮的羟基还原为相应的醇的醛酮还原酶 (AKRs),其具备3-α-羟基类固醇脱氢酶活性,能够以高亲和力结合胆汁酸.在三磷酸吡啶核苷酸存在的情况下,可将二氢睾酮还原成3 α-二醇 (3 α-diol);但在氧化因子NAD+存在的情况下,又可将3 α-二醇氧化为5α-二氢睾酮.AKR1C2在正常组织中含量极低,但在恶性肿瘤组织中表达异常,且与癌症患者的肿瘤特征和长期生存高度相关.AKR1C2作为对人体药物代谢和毒素解 …

Here we report PFOA inhibition of AKR family 1 member C2 (AKR1C2), leading to dysregulation of androgen action. Spectrofluorimetric inhibitor screens identified PFOA as a competitive and tight binding inhibitor of AKR1C2, whose role is to inactivate 5α-dihydrotestosterone (5α-DHT).

Description: Homo sapiens aldo-keto reductase family 1 member C2 (AKR1C2), transcript variant 2, mRNA. (from RefSeq NM_205845) RefSeq Summary (NM_205845): This gene encodes a member of the aldo/keto reductase superfamily, which consists of …