Harmine (7-methoxy-1-methyl-9H-pyrido [3, 4-b]indole) is a tricyclic beta-carboline alkaloid that was originally isolated from seeds of Peganum harmala in 1847. Harmine has been traditionally used for ritual and medicinal preparations in the Middle East, Central Asia and South America.

Harmine is a beta-carboline and a harmala alkaloid. It occurs in a number of different plants, most notably the Syrian rue and Banisteriopsis caapi. [3] Harmine reversibly inhibits monoamine oxidase A (MAO-A), an enzyme which breaks down monoamines, making it a Reversible inhibitor of monoamine oxidase A (RIMA). Harmine does not inhibit MAO-B. [4]

2021年3月30日 · Harmine is a β-carboline alkaloid isolated from Banisteria caapi and Peganum harmala L with various pharmacological activities, including antioxidant, anti-inflammatory, antitumor,...

2015年3月9日 · Using three different mouse and human islet in vivo –based models, we show that harmine is able to induce beta cell proliferation, increase islet mass and improve glycemic control. These...

2025年3月2日 · Harmine, a tricyclic β-carboline alkaloid isolated from the seeds of Peganum harmala L., has emerged as a promising therapeutic candidate owing to its multifaceted biological activities. Recent studies have further highlighted the enhanced therapeutic potential of …

2024年10月30日 · Harmine is a naturally occurring heterocyclic compound belonging to the β-carboline alkaloid class, found in various plants, some animals, insects, and marine organisms. Harmine and its derivatives possess significant pharmacological activities, particularly anticancer properties, making them promising candidates for cancer therapy.

2024年8月22日 · 生物活性： Harmine 是一种天然的双特异性酪氨酸磷酸化调节激酶 (DYRK) 抑制剂，具有抗癌和抗炎活性。 Harmine 对 5-HT2A 血清素受体 具有高亲和力， Ki 为 397 nM [1]。 IC50 和目标：Ki：397 nM（5-HT2A 血清素受体） [1]，DYRK1A [2] 体外： Harmine 通过 DANDY 抑制 DYRK1A 对 tau 的磷酸化，IC50 为 190 nM [2]。 Harmine 通过干扰 Rad51 募集负调节同源重组 (HR)，导致对肝癌细胞有严重的细胞毒性。 此外，NHEJ 抑制剂 Nu7441 显着 …

2024年3月7日 · 本文阐述了 Harmine 是一种有前途的心脏肥大治疗剂，独立于血压调节，通过抑制 NF-κB 磷酸化和病理性心室重塑中刺激的炎性细胞因子可缓解心脏肥大。

2020年11月18日 · Harmine (7-methoxy-1-methyl-9H-pyrido [3,4-b] indole) (Fig. 1) is a β-carboline alkaloid with broad-spectrum anti-inflammatory and antitumor activities. In recent years, harmine has shown great potential in the treatment of diabetes (Wang et al. 2015).

By screening a library of up to 1040 FDA approved compounds and natural products, we identified harmine, a naturally occurring beta-carboline alkaloid, as one of the top hits for turning on the EAAT2 promoter. We demonstrated that harmine effectively increased GLT-1 expression both in vitro and in vivo.