
Acyl-CoA:lysocardiolipin acyltransferase-1 - Wikipedia
ALCAT1 catalyzes remodeling of CL with MLCL and non-linoleic acyl-CoAs like DHA-CoA (C22:6) as substrates, leading to CL peroxidation by ROS and mitochondrial dysfunction.
ALCAT1-mediated abnormal cardiolipin remodelling promotes …
2024年1月10日 · Acyl-coenzyme A:lyso-cardiolipin acyltransferase-1 (ALCAT1) was confirmed to be involved in the progression of Parkinson’s disease, diet-induced obesity and other ageing …
ALCAT1 的心磷脂重塑通过促进线粒体功能障碍将缺氧与冠状动脉 …
Here, we identified acyl-coenzyme A:lysocardiolipin acyltransferase-1 (ALCAT1) as the missing link between hypoxia and CHD in an animal model of myocardial infarction (MI). ALCAT1 is an …
Lysocardiolipin acyltransferase 1 (ALCAT1) controls ... - PNAS
2012年4月16日 · ALCAT1 Causes Mitochondrial Fragmentation and mtDNA Instability in C2C12 Cells. To investigate a role of ALCAT1 overexpression in regulating mitochondria and ER …
Cardiolipin remodeling by ALCAT1 links hypoxia to coronary …
2021年12月1日 · ALCAT1 is an acyltransferase that promotes mitochondrial dysfunction in aging-related diseases by catalyzing pathological remodeling of cardiolipin. In support of a causative …
Cardiolipin remodeling by ALCAT1 links hypoxia to coronary …
2021年12月1日 · Here, we identified acyl-coenzyme A:lysocardiolipin acyltransferase-1 (ALCAT1) as the missing link between hypoxia and CHD in an animal model of myocardial infarction …
ALCAT1 controls mitochondrial etiology of fatty liver diseases, …
ALCAT1 is a lysocardiolipin acyltransferase that catalyzes pathological cardiolipin remodeling in several aging-related diseases. We show that the onset of diet-induced NAFLD caused …
Pharmacological inhibition of ALCAT1 mitigates amyotrophic …
2022年9月1日 · Using mice with transgenic expression of the SOD1G93A as a mouse model of ALS, we investigated a role of ALCAT1 in regulating the onset and development of ALS. We …
Cardiolipin remodeling by ALCAT1 links mitochondrial …
2019年3月5日 · Using mice with targeted deletion of ALCAT1, we investigated a role for the enzyme in regulating the onset of MPTP-induced PD. We show that upregulated ALCAT1 …
ALCAT1 is a polyglycerophospholipid acyltransferase potently …
Acyl-CoA:lysocardiolipin acyltransferase-1 (ALCAT1) catalyzes acylation of lysocardiolipin back to cardiolipin, an important step in cardiolipin remodeling. The present study reports the catalytic …
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