ALCAT1 catalyzes remodeling of CL with MLCL and non-linoleic acyl-CoAs like DHA-CoA (C22:6) as substrates, leading to CL peroxidation by ROS and mitochondrial dysfunction.

2024年1月10日 · Acyl-coenzyme A:lyso-cardiolipin acyltransferase-1 (ALCAT1) was confirmed to be involved in the progression of Parkinson’s disease, diet-induced obesity and other ageing …

Here, we identified acyl-coenzyme A:lysocardiolipin acyltransferase-1 (ALCAT1) as the missing link between hypoxia and CHD in an animal model of myocardial infarction (MI). ALCAT1 is an …

2012年4月16日 · ALCAT1 Causes Mitochondrial Fragmentation and mtDNA Instability in C2C12 Cells. To investigate a role of ALCAT1 overexpression in regulating mitochondria and ER …

2021年12月1日 · ALCAT1 is an acyltransferase that promotes mitochondrial dysfunction in aging-related diseases by catalyzing pathological remodeling of cardiolipin. In support of a causative …

2021年12月1日 · Here, we identified acyl-coenzyme A:lysocardiolipin acyltransferase-1 (ALCAT1) as the missing link between hypoxia and CHD in an animal model of myocardial infarction …

ALCAT1 is a lysocardiolipin acyltransferase that catalyzes pathological cardiolipin remodeling in several aging-related diseases. We show that the onset of diet-induced NAFLD caused …

2022年9月1日 · Using mice with transgenic expression of the SOD1G93A as a mouse model of ALS, we investigated a role of ALCAT1 in regulating the onset and development of ALS. We …

2019年3月5日 · Using mice with targeted deletion of ALCAT1, we investigated a role for the enzyme in regulating the onset of MPTP-induced PD. We show that upregulated ALCAT1 …

Acyl-CoA:lysocardiolipin acyltransferase-1 (ALCAT1) catalyzes acylation of lysocardiolipin back to cardiolipin, an important step in cardiolipin remodeling. The present study reports the catalytic …