2024年12月24日 · ALDH1A2 (Aldehyde Dehydrogenase 1 Family Member A2) is a Protein Coding gene. Diseases associated with ALDH1A2 include Diaphragmatic Hernia 4, With Cardiovascular Defects and Renal Hypodysplasia/Aplasia 1. Among its related pathways are Signaling by Retinoic Acid and ESR-mediated signaling.

Aldehyde Dehydrogenase 1, Family Member A2 (ALDH1A2) is essential for the synthesis of retinoic acid from vitamin A. Studies in model organisms demonstrate a critical role for ALDH1A2 in embryonic development, yet few pathogenic variants are linked to …

2022年12月21日 · Here Zhu et al. identify variants in the ALDH1A2 gene, responsible for the synthesis of all-trans retinoic acid (atRA), in patients with severe hand OA and link risk alleles to cartilage injury and inflammation.

The Presence and Potential Role of ALDH1A2 in the Glioblastoma Microenvironment. Peanut protein acts as a TH2 adjuvant by inducing RALDH2 in human antigen-presenting cells. ALDH1A2 and ALDH1A3 showed higher catalytic efficiency for all-trans-retinaldehyde. Magnesium inhibited ALDH1A1 and ALDH1A2, while it activated ALDH1A3.

2025年1月4日 · Acquired resistance of leukemic cells to AraC is associated with the upregulation of aldehyde dehydrogenase 1 family member A2. Methylation of a CpG site near the ALDH1A2 gene is associated with loss of control over drinking and related phenotypes.

Aldehyde Dehydrogenase 1, Family Member A2 (ALDH1A2) is essential for the synthesis of retinoic acid from vitamin A. Studies in model organisms demonstrate a critical role for ALDH1A2 in embryonic development, yet few pathogenic variants are linked to …

ALDH1A2 catalyzes the lipid peroxidation (LPO)-derived aldehydes and may eliminate the damage of oxidative stress. The ALDH1A2 of rat oxidizes the medium-chain saturated LPO-derived aliphatic aldehydes with the high affinity of hexanal, octanal and decanal 40.

2025年2月8日 · We have identified the retinoic acid synthesis enzyme Aldh1a2 gene as a principal target of bone morphogenetic protein (BMP) signaling; prochondrogenic BMPs or growth-differentiation factors attenuate Aldh1a2 expression and the retinoid signaling pathway

The ALDH1A2 gene encodes a member of the aldehyde dehydrogenase gene family and plays a role in the production of retinoic acid (RA), which is an important signaling molecule during development (summary by Beecroft et al., 2021).

ALDH1A2 catalyzes the irreversible oxidation of all-trans-retinal and 9-cis-retinal to retinoic acid (Duester 2000). When compared to other retinal-oxidizing ALDHs, ALDH1A2 exhibits the highest specificity for all-trans-retinal (Duester et al. 2003; Zhao et al. 1996).