2024年12月24日 · ALDH1L2 (Aldehyde Dehydrogenase 1 Family Member L2) is a Protein Coding gene. Diseases associated with ALDH1L2 include Sjogren-Larsson Syndrome and Succinic …

该成员是 10-甲酰四氢叶酸脱氢酶 (FDH) 的线粒体形式，它在 NADP (+) 依赖性反应中将 10-甲酰四氢叶酸转化为四氢叶酸和 CO2，并且在细胞溶质之间的单碳基团分布中起重要作用和细胞 …

Aldehyde dehydrogenase 1 family, member L2 also known as ALDH1L2 is an enzyme that in humans is encoded by the ALDH1L2 gene. [5][6] ALDH1L2 is the mitochondrial isoform of a …

2025年1月1日 · ALDH1L2 promotes HCC progression by activating the IL-6/Jak2/STAT3 signaling axis and promoting TAM polarization. ALDH1L2 knockdown sensitizes HCC cells to …

2025年2月8日 · ALDH1L2 regulation of formate, formyl-methionine, and ROS controls cancer cell migration and metastasis. ALDH1L2 has enzymatic properties similar to its cytosolic counterpart

2024年12月30日 · 本文详细介绍了ALDH1L2基因的功能、作用机制、信号通路及其与疾病的关系，帮助读者全面理解这一基因在生物体内的重要作用。 ALDH1L2，全称醛脱氢酶1家族成 …

One of these enzymes—aldehyde dehydrogenase 1 family member 2 (ALDH1L2)—produces NADPH by catabolizing 10-formyl-THF into CO 2 and THF. Using breast cancer cell lines, we …

ALDH1L2 enables sufficient NADPH production in mitochondria to maintain high levels of glutathione, which in turn is required to support high levels of cysteine, the coenzyme A …

2019年7月23日 · Our study underscores the role of ALDH1L2 in the maintenance of mitochondrial integrity and energy balance of the cell, and suggests the loss of the enzyme as the cause of …

2023年9月1日 · In this study, we observed the significant overexpression of ALDH1L2 in colorectal cancer (CRC) tissues, which is associated with poor prognosis. Mechanistically, we …