Inverted Alu repeats: friends or foes in the human transcriptome ...
2024年6月14日 · When two Alu elements with inverse orientations are positioned in close proximity, their transcription results in the generation of distinct double-stranded RNAs …
Inverted Alu dsRNA structures do not affect localization but can …
We observed that two Alu elements in inverted orientation within the 3′-UTR of human mRNAs give rise to dsRNA. Although the structures are extensively edited in vivo, the presence of …
Alu insertion-mediated dsRNA structure formation with pre-existing Alu ...
2024年10月3日 · We provide compelling evidence to link the detrimental effect of Alu _Ins to extensive dsRNA structures formed between Alu _Ins and pre-existing intronic Alu sequences, …
【科技前沿】Nature | 薛愿超团队揭示基因组重复元件Alu调控转录 …
2023年7月12日，来自中国科学院生物物理研究所的薛愿超团队在Nature杂志在线发表题为Complementary Alu sequences mediate enhancer-promoter selectivity 的文章。该研究基 …
Alu RNA Structural Features Modulate Immune Cell Activation
2022年1月19日 · Alu RNA is abundant in cells and its repetitive structure forms double-stranded RNAs (dsRNA) that activate dsRNA sensors and trigger innate immune responses with …
Alu RNA Structural Features Modulate Immune Cell Activation
2022年1月20日 · Alu RNA is abundant in cells and its repetitive structure forms double-stranded RNAs (dsRNA) that activate dsRNA sensors and trigger innate immune responses with …
Adenosine-to-Inosine RNA Editing of Alu Double-Stranded (ds
2020年11月15日 · We find widespread loss of adenosine-to-inosine editing of Alu RNAs in MS. Unedited Alu RNAs are potent activators of both IFN and NF-κB responses via the dsRNA …
Inverted Alu dsRNA structures do not affect localization but can …
2012年9月1日 · It is possible that long dsRNA structures formed from Alu elements influence gene expression. Here, we report that human mRNAs containing inverted Alu elements are …
Endogenous double-stranded Alu RNA elements stimulate IFN …
2019年6月1日 · Endogenous Alu and Line double stranded RNAs may be the source of type 1 IFN responses in relapsing remitting multiple sclerosis and possibly other human autoimmune …
Alu RNA 结构特征调节免疫细胞激活，Alu RNA 的 A-to-I 编辑在 …
Alu RNA is abundant in cells and its repetitive structure forms double-stranded RNAs (dsRNA) that activate dsRNA sensors and trigger innate immune responses with significant pathological …