2009年8月1日 · Instead of treating the wound open, an alternative is to implant antibiotic impregnated polymethylmethacrylate (AIPMMA) beads which release relatively high concentration of antibiotic locally with little systemic absorption. This allows primary closure of the site and eliminates the need for open wound care.

This study demonstrated that liquid amikacin could be incorporated into ALBC and used to treat MSK infections, particularly NTM PJI. Liquid amikacin was successfully incorporated into PMMA bone cement. We did not find any systemic or local ADRs definitively related to their use in our small number of patients.

2023年5月1日 · To compare the elution characteristics of amikacin-impregnated calcium sulfate (CaSO 4) beads based on different drug concentrations and bead size configurations. Six groups of amikacin-impregnated CaSO 4 beads and one negative control group.

2023年3月11日 · Amikacin-impregnated CaSO4 beads achieved extreme supratherapeutic eluent concentrations. While additional studies are needed, bead size significantly affected elution with smaller beads reaching higher peak concentrations and 7 mm, high-concentration beads demonstrating a longer therapeutic duratio …

One method of ensuring high concentrations of antibiotics at the site of infection with reduced systemic side effects is the use of AIPMMA beads. A variety of heat-stable antimicrobials may be used in PMMA beads including gentamycin, amikacin, neomycin, lincomycin and clindamycin (Marks, et aI, 1976, Wahlig and Dingeldein, 1980).

2024年8月4日 · In conclusion, CSH beads impregnated with amikacin, cefazolin, gentamicin, and meropenem eluted antibiotics over the 30-day course of the study with most of the antibiotic elution occurring within the first week. Larger beads maintained higher concentrations for a longer period, consistent with a previous study . Ampicillin/sulbactam was not ...

2024年8月5日 · Introduction: The use of implantable antibiotic beads has become a frequent treatment modality for the management of surgical site infections in human and veterinary medicine. The objective of this study is to describe the elution kinetics of five antibiotics from a commercially available calcium sulfate antibiotic delivery kit.

NOTE: For slower setting antibiotics (example: Amikacin), a Non-Standard technique should be used to reduce set time. Mixing KERRIER powder with mixing solution (saline) first, without antibiotic, will accelerate the setting process. It is advisable to prepare beads within a sterile field prior to the start of a surgical case.

2023年3月11日 · 15 different antibiotics were individually mixed with commercially available calcium sulfate bone void filler beads. The antibiotics were: amikacin, ceftriaxone, cefuroxime, ciprofloxacin ...

2010年8月2日 · The short duration of antimicrobial inhibition associated with eluent from amikacin-only containing POP beads calls into question their appropriateness for local treatment of clinical infections caused by multidrug-resistant Staphylococcus spp. Combining amikacin beads with vancomycin beads could result in effective inhibition of resistant ...