Exposing bacteria to antibiotics can accelerate the emergence of AMR and spread of antibiotic-resistant bacteria . Under the antibiotic stimulus, bacterial SOS responses can be activated for self-saving .

Beaber等人61发现，SOS反应介导了抗生素诱导的HGT。SOS反应由LexA（SOS阻遏物）和RecA（SOS诱导物）蛋白质控制。RecA的辅蛋白酶活性促进LexA蛋白的自切割，导致SOS反应的诱导（图4）。

2024年5月16日 · Furthermore, we demonstrate that as a potent inhibitor of the mutagenic SOS response, OXF-077 suppresses the rate of ciprofloxacin resistance emergence in S. aureus. This work supports SOS-response inhibitors as a novel means to combat AMR, and delivers OXF-077 as a tool molecule for future development.

Understanding the underlying molecular basis of antimicrobial resistance (AMR) is pertinent to develop new drugs or design appropriate strategies to prevent the emergence of resistance. The present chapter is a ready reckoner for the mode of action of antibiotics, mechanism of AMR, and transfer of its resistance.

2024年5月16日 · Furthermore, we demonstrate that as a potent inhibitor of the mutagenic SOS response, OXF-077 suppresses the rate of ciprofloxacin resistance emergence in S. aureus. This work supports SOS-response inhibitors as a novel means to combat AMR, and delivers OXF-077 as a tool molecule for future development. 中文翻译：

2022年8月3日 · Dissemination of antimicrobial resistance (AMR) genes by horizontal gene transfer (HGT) mediated through plasmids is a major global concern. Genomic epidemiology studies have shown varying success of different AMR plasmids during outbreaks, but the underlying reasons for these differences are unclear.

几种病原体的抗菌素耐药性（amr）特性是全球关注的主要问题之一，需要不断创新才能得到控制。 由 LexA 和 RecA 调节的细菌 SOS 反应通过有利的突变促进 AMR。

2024年5月16日 · 细菌 dna 修复和 sos 反应途径可促进病原体在感染环境中的存活，并激活超突变和耐药机制，使这些途径成为新疗法的有吸引力的目标。 小分子，如IMP-1700 ，可增强 DNA 损伤并抑制耐甲氧西林金黄色葡萄球菌的 SOS 反应；然而，人们对这个系列的构效关系（SAR ...

细菌dna修复和sos反应途径促进病原体在感染环境中的生存，并且激活高突变率和耐药机制，使这些途径成为新型治疗药物的吸引点。 研究内容 在这项研究中，研究人员发现了一种名为IMP-1700的小分子，它加剧DNA损伤并抑制了甲氧西林耐甲氧西林金黄色葡萄球菌的 ...

2024年9月17日 · “The six leading pathogens for deaths associated with resistance (Escherichia coli, followed by Staphylococcus aureus, Klebsiella pneumoniae, Streptococcus pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa) were responsible for 929 000 (660 000–1 270 000) deaths attributable to AMR and 3·57 million (2·62–4·78) deaths ...