GN and vasculitis caused by ANCAs is the most common form of new-onset GN in adults >50, although it can occur at any age. Prompt diagnosis and initiation of appropriate immunosuppressive therapy is essential for optimum patient and renal outcomes.

Patients with ANCA-associated vasculitis, lymphocytapheresis versus standard of care – intravenous methylprednisone, glucocorticoids, and cyclophosphamide Table S26.

ANCA vasculitis is a type of autoimmune disease that causes vasculitis. ANCA stands for Anti-Neutrophilic Cytoplasmic Autoantibody. All of these terms will be explained here, including how the disease works and what we can do for it.

2017年10月6日 · Pauci-immune necrotizing and crescentic GN is a frequent component of ANCA vasculitis. ANCA vasculitis is associated with ANCA specific for myeloperoxidase (MPO-ANCA) or proteinase 3 (PR3-ANCA). A diagnosis of ANCA vasculitis should always specify the serotype as MPO-ANCA positive, PR3-ANCA positive, or ANCA-negative.

2024年9月19日 · Here, using spatial and single-cell transcriptome analysis, we characterize inflammatory niches in kidney samples from 34 patients with ANCA-GN and identify proinflammatory, cytokine-producing...

2022年6月22日 · Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis is a destructive small vessel vasculitis affecting multiple organs. Renal involvement often leads to end-stage renal disease and increases mortality. Prompt diagnosis and initiation of adequate immunosuppressive therapy are critical for the best patient and kidney outcomes.

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a spectrum of conditions characterized by inflammation of the small- and medium-sized vasculature. Glomerulonephritis associated with AAV (AAV-GN) exerts a profound effect on ...

2020年12月23日 · Hydralazine, a widely used therapy for hypertension and heart failure, can elicit autoimmune disease, including anti-neutrophil cytoplasmic antibody associated glomerulonephritis (ANCA-GN). We identified 80 cases of ANCA-GN complicating treatment with hydralazine, accounting for 4.3% (80/1858 biopsies) of ANCA-GN diagnosed between 2006 and 2019.

2021年1月7日 · 抗中性粒细胞胞质抗体（anti-neutrophil cytoplasmic antibody，ANCA）相关肾炎（ANCA-associated glomerulonephritis，AAGN）是造成中老年肾脏病患者急性肾功能减退的主要原因，病情严重，人肾存活率低。

2024年5月1日 · 抗中性粒细胞胞质抗体（ANCA）介导肾小球肾炎（GN）表现为节段性坏死性病变以及节段性或环状细胞新月体，可不同程度地压迫肾小球毛细血管簇。 一例59岁抗蛋白激酶3抗体滴度高、肾功能衰竭患者ANCA-GN的肾小球周围活动性炎症，呈环状新月形充满鲍曼囊。 尽管ANCA-GN通常很少或没有免疫球蛋白，但有时可见散在的免疫复合物沉积，如本例中所示为IgG染色。 此外，还可以看到1+或更低的IgM、C3，甚至IgA。 1例84岁女性髓质毛细血管炎伴中性 …