Angiotensin (1-7) (C 41 H 62 N 12 O 11; Molecular weight = 899.02 g/mol; H-Asp-Arg-Val-Tyr-Ile-His-Pro-OH) is an active heptapeptide of the renin–angiotensin system (RAS). [1] It also known by the generic name talfirastide (development name TXA127). [2]

Angiotensin 1-7 (Ang-(1-7)) is an endogenous heptapeptide from the renin-angiotensin system with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 inhibits purified canine ACE activity ( IC 50 =0.65 μM).

2024年3月14日 · Angiotensin 1-7 (Ang- (1-7)) 是 血管紧张素系统 (RAS) 中的一种内源性七肽，由于其在心肌细胞中的抗炎和 抗纤维化活性 而具有 心脏保护作用。 Angiotensin 1-7 通过抑制血管紧张素转换酶和释放一氧化氮，可作为激肽诱导的血管舒张的局部协同调节剂。 Angiotensin 1-7 阻断 Ang II 诱导的平滑肌细胞增殖和肥大，并显示对内皮的抗血管生成和生长抑制作用。 Angiotensin 1-7 显示出抗炎活性。 包装与运输: 低温、无害化学品装运，根据要求精确到毫克 …

Angiotensin- (1-7) is a vasoactive peptide of the renin–angiotensin system (RAS), which is generated mainly by angiotensin-converting enzyme 2 (ACE2) and exerts its actions via activation of its receptor Mas.

2014年3月24日 · There is a vast array of literature concerning the effects of Ang- (1–7) in the heart. Averill et al 9 were the first to report the presence of Ang- (1–7) immunoreactivity within myocytes in the rat heart.

Angiotensin- (1-7) is a vasoactive peptide of the renin–angiotensin system (RAS), which is generated mainly by angiotensin-converting enzyme 2 (ACE2) and exerts its actions via activation of its receptor Mas.

Ang 1-7 exerts its effects on blood pressure via three important organ systems: the brain, vascular system and the kidney. The essential role of Ang 1-7 in hypertension is to modulate renal flow by prompting vasodilation and counterbalancing Ang II-induced vasoconstriction.

Ang III [Ang-(2-8)]是一种通过去除第一个n端氨基酸而形成的七肽，存在于中枢神经系统(CNS)中，被认为在维持强直性血压和高血压中起重要作用。Ang IV [Ang-(3-8)] 是Ang III进一步酶解后形成的六肽。临床前研究表明Ang IV在Ang II信号中有协同作用。

2017年9月19日 · Here we show that Ang- (1-7) binds to the AT1R without activating Gq, but triggering β-arrestins 1 and 2 recruitment and activation. Using an in vivo model of cardiac hypertrophy, we show that...

1999年2月1日 · 近年来的研究发现:Ang- (1-7)可以由Ang Ⅰ和Ang Ⅱ转化而成,Ang- (1-7)具有扩张血管降压、利尿、抑制平滑肌细胞生长的作用,这些作用与缓激肽、一氧化氮、前列腺素有关,通过一种特殊的受体介导。 Ang- (1-7)的深入研究将有助于与Ang Ⅱ有关疾病的防治。 血管紧张素 (Ang)- (1-7)是由Ang Ⅰ和AngⅡ转化成的7肽生物活性产物。 以往的研究认为Ang- (1-7)具有Ang Ⅱ作用。 然而,近年来的研究结果却不同 [1～3]。 本文就此做一简述。