2020年3月26日 · Hydroxyapatite augments AngII (angiotensin II)-induced abdominal aortic aneurysms, accompanied by profound macrophage infiltration. Vascular smooth muscle …

Silencing of RUNX2 ameliorates AngII-induced AAA in vivo. To evaluate the possible effect of RUNX2 on aneurysm formation in vivo, we induced AAA in male apolipoprotein E knockout …

We aimed to evaluate the roles of RUNX2 and its putative downstream target miR-424/322 in the modulation of several AAA progression-related key molecules, such as matrix metal …

2024年8月7日 · In essential hypertension, the renin–angiotensin–aldosterone system (RAAS) is extensively activated, and the expression of its main effector angiotensin II (AngII) is upregulated.

Consistently, vascular smooth muscle cell-specific Runx2 deficiency markedly repressed AngII-induced AAA formation in the ApoE-/-mice compared with the control littermates. Conclusions: …

2024年8月7日 · The miR/RAS/RUNX2 autophagy network driven by H 2 S donors was related to hypertensive nephropathy. H 2 S donors or miRNAs increased autophagic flux and reduced …

We found that silencing RUNX2 also attenuated AngII-induced neovascularization (CD31); leukocytes (CD45, leukocyte common antigen), and macrophage (CD68, macrophage) …

muscle cell–specific Runx2 deficiency markedly repressed AngII-induced AAA formation in the −/− mice compared ApoE with the control littermates. CONCLUSIONS: Our studies have revealed …

2020年3月26日 · role of the osteogenic factor Runx2 in mediating AngII- induced microcalcification and aortic inflammation, which provides novel insights into the mechanism …

2021年12月21日 · We aimed to evaluate the roles of RUNX2 and its putative downstream target miR-424/322 in the modulation of several AAA progression-related key molecules, such as …