Here we outline the application of the Azoxymethane (AOM)/Dextran sodium sulfate (DSS) model of CAC. The AOM/DSS model is a powerful, reproducible, and relatively inexpensive initiation …

Dec 14, 2020 · In the AOM–DSS model, symptoms are caused by flares of colitis during the cycles of DSS treatment. Intestinal inflammation accompanies changes in body weight and …

Here we describe the Azoxymethane (AOM)/Dextran Sodium Sulfate (DSS) mouse model of inflammatory colorectal cancer. Keywords: AOM; Colitis-associated cancer; Colon cancer; …

AOM/DSS模型 是目前使用最广泛的 UC化学诱导模型，临床症状学、形态学及病理学观察证明，该模型与人类 溃疡性结肠炎 癌变过程极为相似。 AOM引起 鸟嘌呤O6甲基化 是诱导 基因 …

Mar 24, 2011 · In this article we highlight the histopathological and molecular features and describe the principal genetic and epigenetic alterations and inflammatory pathways involved …

Furthermore, it was demonstrated that an AOM/DSS model with a low dose of DSS (1%) can be used to reliably induce colorectal carcinogenesis measured as preneoplastic lesions in both …

The combination of DSS with AOM as a model for colitis associated cancer has gained popularity for its reproducibility, potency, low price, and ease of use. Though they have a shared …

Oct 26, 2023 · This has been a challenge to model in mice with commonly used azoxymethane/dextran sodium sulfate (AOM/DSS), which couples the mutagenic substance …

Jul 27, 2021 · We show that colonic preneoplastic lesions can be reliably detected in A/J and B6 mice by use of a AOM/DSS model involving a single injection of 10 mg/kg AOM followed by …

Nov 12, 2019 · In this article we optimized the protocol of the AOM-DSS modeling using C57BL/6 mice for study on sporadic CRC by intraperitoneal injecting AOM solution at a proper …