035169 B6.Cg- Kras tm4Tyj Apc tm1Tno Tg(CDX2-cre/ERT2)752Erf/MaraJ The inducible KPC:APC mouse model of KRAS mutated colorectal cancer combines the oncogenic conditional Kras G12D allele, the conditional Apc fl allele and a tamoxifen inducible Cre recombinase (CDX2-Cre-ER T2 ) with cre expression in adult epithelium of the distal intestinal tract.

kpc小鼠是目前成功建立的一种胰腺导管腺癌模型小鼠，具有很多与人胰腺癌相似的特点，如胰腺内皮细胞瘤形成，强烈的免疫反应。 80%的KPC小鼠出现了肝转移和肺转移的现象。

2022年11月11日 · KPC小鼠携带LSL-KrasG12D、LSL-Trp53R172H和Pdx1-Cre三种基因型，是最完美的自发胰腺癌小鼠模型之一，它与人类胰腺癌的关键特征非常相似。 KPC模型可用作胰腺导管腺癌（PDAC）的模型 ，并且由于该模型体内的肿瘤有转移倾向，因此 KPC小鼠可用于研究原发性 …

2022年10月25日 · kpc小鼠是目前成功建立的一种胰腺导管腺癌模型小鼠，具有很多与人胰腺癌相似的特点，如胰腺内皮细胞瘤形成，强烈的免疫反应。 80%的KPC小鼠出现了肝转移和肺转移的现象。

2019年11月13日 · In this study C57 BL/6 mice with truncated adenomatous polyposis coli (APC) floxed allele was crossed with heterozygous KRAS floxed outbred mice to generate an APCf/f KRAS+/f mouse colony. In...

View mouse strain B6.Cg-Kras<tm4Tyj> Apc<tm1Tno> Tg (CDX2-cre/ERT2)752Erf/MaraJ : mutations, QTL, phenotypes, diseases, and references.

The model KPC: APC animals are conditional mutants that developed colonic tumors upon induction with tamoxifen in a dose-dependent manner. The tumors were confirmed to be malignant within four weeks of induction by H&E staining and higher radioactive [18F] fluoro-2-deoxyglucose (FDG) uptake (SUV) in micro-PET scan.

The model KPC: APC animals are conditional mutants that developed colonic tumors upon induction with tamoxifen in a dose-dependent manner. The tumors were confirmed to be malignant within four weeks of induction by H&E staining and higher radioactive [18F] fluoro-2-deoxyglucose (FDG) uptake (SUV) in micro-PET scan.

与此相似的品系还有kpc，详细信息请咨询技术顾问。 应用领域 ：自发胰腺癌模型 *使用本品系发表的文献需注明: KPC(2) mice (Cat. NO. NM-KI-220014) were purchased from Shanghai Model Organisms Center, Inc..

2019年11月13日 · The model KPC: APC animals are conditional mutants that developed colonic tumors upon induction with tamoxifen in a dose-dependent manner. The tumors were confirmed to be malignant within four weeks of induction by H&E staining and higher radioactive [18F] fluoro-2-deoxyglucose (FDG) uptake (SUV) in micro-PET scan.