2020年2月19日 · Wnt/β-catenin signaling is essential for intestinal homeostasis and is aberrantly activated in most colorectal cancers (CRC) through mutation of the tumor suppressor Adenomatous Polyposis...

典型Wnt/β-catenin信号通路（Canonical Wnt/β-catenin pathway），此通路激活核内靶基因的表达； Wnt家族分泌蛋白、Frizzled家族跨膜受体蛋白Dishevelled（Dsh）、糖原合成激酶3（GSK3）、APC、Axin、β-连环蛋白及TCF/LEF家族 转录调节因子等构成了经典通路； [3]

Wnt 配体是一种分泌型糖蛋白，可结合 Frizzled (卷曲）受体，然后与 LRP5/6 一起在细胞表面形成一个更大的复合体。 卷曲受体被 ZNRF3 和 RNF43 泛素化，二者的活性可通过 R-spondin 结合到 LGR5/6 而受到抑制。

2023年6月4日 · Wnt信号通路是胚胎及器官发育的重要信号通路之一，参与调控机体内多种细胞的增殖、分化、极化、迁移及凋亡等过程。Wnt信号通路根据是否依赖于 β-catenin的转录活化，可分为经典通路（即 Wnt／β-catenin信号通路…

2023年7月19日 · Here, we demonstrate the role of oncogenic APC in increasing plasma membrane free cholesterol and rigidity, thereby modulating Wnt signaling hubs. This results in an overactivation of Wnt...

2022年1月3日 · In the cytoplasm, a “destruction complex” comprising adenomatous polyposis coli (APC), AXIN, casein kinase 1 (CK1) and glycogen synthase kinase 3 protein (GSK3 protein) captures β-catenin by ...

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion , transcriptional activation, and apoptosis .

Wnt/β-catenin signaling is essential for intestinal homeostasis and is aberrantly activated in most colorectal cancers (CRC) through mutation of the tumor suppressor Adenomatous Polyposis Coli (APC). APC is an essential component of a cytoplasmic protein …

2020年2月19日 · Wnt/β-catenin signaling is essential for intestinal homeostasis and is aberrantly activated in most colorectal cancers (CRC) through mutation of the tumor suppressor Adenomatous Polyposis Coli (APC). APC is an essential component of a cytoplasmic protein complex that targets β-catenin for destructio …

Apc−/−CM孵育的WT类器官显示出干性下降和分化增加的特征，这可以通过WNT和ISC的表达减少来证明。数据表明apc突变小鼠和人类细胞分泌因子，通过促进分化和减少干细胞数量，积极抑制WT类器官的生长和克隆性。