APE 1 - NEB
人源脱嘌呤/脱嘧啶（AP）核酸内切酶 APE 1，也称为 HAP 1 或 Ref-1，与大肠杆菌核酸外切酶 III 蛋白具有同源性。 APE 1 水解断裂脱嘌呤/脱嘧啶位点 5´ 端的磷酸二酯键，产生单链 DNA 断 …
APE 1 - NEB
Human apurinic/apyrimidinic (AP) endonuclease, APE 1, also known as HAP 1 or Ref-1, shares homology with Escherichia coli exonuclease III protein. APE 1 cleaves the phosphodiester …
APE1介导的功能核酸生物传感器研究进展 - 仁和软件
脱嘌呤/脱嘧啶核酸内切酶1(Apurinic/apyrimidinic endonuclease 1，APE1)是一种广泛存在于生物体内、在碱基切除修复(Base excision repair，BER)过程中能够在碱基缺失位点(AP site)处识 …
The Many Functions of APE1/Ref-1: Not Only a DNA Repair Enzyme
APE1 is the main apurinic/apyrimidinic endonuclease in eukaryotic cells, playing a central role in the DNA base excision repair pathway of all DNA lesions (uracil, alkylated and oxidized, and …
Structural basis for APE1 processing DNA damage in the …
2022年9月14日 · Here, we determine how the base excision repair (BER) endonuclease AP-endonuclease 1 (APE1) recognizes and cleaves DNA damage in the nucleosome. Kinetic …
Molecular beacon-based DNA tetrahedrons for APE 1
2022年3月15日 · In this report, a new tetrahedral molecular beacon (TMB) probe is designed for the detection of APE 1 activity. This probe not only has the advantage that the tetrahedron can …
Small-molecule inhibition of APE1 induces apoptosis ... - Nature
2021年5月18日 · Apurinic/apyrimidinic endonuclease 1 (APE1) plays a critical role in the base excision repair (BER) pathway, which is responsible for the excision of...
无嘌呤核酸内切酶 1 | Apurinic endonuclease 1 (APE1) | MCE
Apurinic endonuclease 1 (APE1) is one of the key enzyme in the DNA base excision repair system. APE1 hydrolyzes DNA adjacent to the 5'-end of an apurinic/apyrimidinic (AP) site to …
脱嘌呤嘧啶核酸内切酶 - 百度百科
脱嘌呤嘧啶核酸内切酶（apurinic/apyrimidinic (AP) endonuclease，简称APE）是一种生物酶。 Apurinic/apyrimidinic (AP) endonuclease (BRENDA = 4.2.99.18) APE参与 碱基切除修复。 在 …
APE1介导的功能核酸生物传感器研究进展
摘要： 脱嘌呤/脱嘧啶核酸内切酶1（Apurinic/apyrimidinic endonuclease 1,APE1）是一种广泛存在于生物体内、在碱基切除修复（Base excision repair,BER）过程中能够在碱基缺失位 …