Apolipoprotein A1 (ApoA1) is the primary protein associated with high-density lipoprotein (HDL) particles, and plays a central role in reverse cholesterol transport. HDL cholesterol (HDL-C) and ApoA1 concentrations are inversely related to the risk for coronary artery disease (CAD).

Apolipoprotein A-I (ApoA-I), the major protein component of high density lipoprotein (HDL), widely known for regulating cholesterol trafficking and for protecting against cardiovascular disease (CVD), may also modulate inflammatory and immune responses [1].

Dec 24, 2024 · APOA1 (Apolipoprotein A1) is a Protein Coding gene. Diseases associated with APOA1 include Hypoalphalipoproteinemia, Primary, 2 and Amyloidosis, Hereditary Systemic 3 . Among its related pathways are Plasma lipoprotein assembly, remodeling, and clearance and Response to elevated platelet cytosolic Ca2+ .

Mutations in the APOA1 gene cause familial HDL deficiency, an inherited condition characterized by low levels of HDL in the blood and an elevated risk for early-onset cardiovascular disease, which often occurs before age 50. These mutations lead to an altered apoA-I protein.

Feb 16, 2021 · Purpose of the review: Apolipoprotein (APO) A1, the main apolipoprotein of plasma high-density lipoproteins (HDLs), has several well documented cardioprotective functions. A number of additional potentially beneficial functions of APOA1 have recently been identified.

Apr 6, 2024 · Cardiovascular events frequently recur after acute myocardial infarction, and low cholesterol efflux — a process mediated by apolipoprotein A1, which is the main protein in high-density...

Low levels of apolipoprotein A1 (ApoA1) confer increased risk of atherosclerotic cardiovascular disease. ApoA1 below 25 mg/dL may aid in the detection of a genetic disorder such as Tangier disease. ApoA1 is often interpreted as a ratio with apolipoprotein B (ApoB).

ApoA1 is the major apolipoprotein in the HDL particles. ApoA1 is a main initiator and “driver of the reverse cholesterol transport”. ApoA1 can also manifest anti-oxidant and anti-inflammatory effects, so it can stimulate both endothelial production of nitric oxide as well as release of prostacyclin from the endothelium. Thus, apoA1 ...

Feb 8, 2025 · ApoA1 enhances resolution of allergen-induced airway inflammation through promoting recovery of damaged TJs in the bronchial epithelium. APOA1 is compact with four helical regions, amino acids 44-186, bundled together. Hereditary apolipoprotein A-I amyloidosis is characterized by slowly progressive renal disease.

APOA1 is the major protein component of high density lipoprotein (HDL) in plasma and is primarily synthesized in liver and small intestine (summary by Halley et al., 2014).