The primary translation product of the APOA4 gene is a 396-residue preprotein, which undergoes proteolytic processing to yield apo A-IV, a 376-residue mature O-linked glycoprotein. In most mammals, including humans, apo A-IV synthesis is confined to the …

apol-iv, apoliv 这个基因编码载脂蛋白L家族的一个成员。 编码的蛋白质可能在全身的脂质交换和转运中起作用，也可能在胆固醇从外周细胞向肝脏的逆向转运中起作用。

Apolipoprotein A-IV (apoA-IV) is a lipid-binding protein, which is primarily synthesized in the small intestine, packaged into chylomicrons, and secreted into intestinal lymph during fat absorption. In the circulation, apoA-IV is present on chylomicron remnants, high-density lipoproteins, and also in …

Apolipoprotein A-IV (apoA-IV) is secreted by the small intestine on chylomicrons into intestinal lymph in response to fat absorption. Many physiological functions have been ascribed to apoA-IV, including a role in chylomicron assembly and lipid ...

2015年8月1日 · ApoA-IV is primarily synthesized by the small intestine, attached to chylomicrons by enterocytes, and secreted into intestinal lymph during fat absorption. In circulation, apoA-IV is associated with HDL and chylomicron remnants, but a large portion is lipoprotein free.

ApoA-IV was discovered 40 years ago as a major protein component of chylomicrons in postprandial lymph and plasma of both humans and rats (1–3). In plasma it is found on chylomicrons and on HDL, but 40–50% circulates lipid free (1–3). The presence of apoA-IV in the blood is uniquely linked to the absorption and secretion of dietary lipid.

2019年4月5日 · Apolipoprotein A-IV (apoA-IV) is a lipid-binding protein, which is primarily synthesized in the small intestine, packaged into chylomicrons, and secreted into intestinal lymph during fat absorption. In the circulation, apoA-IV is present on chylomicron remnants, high-density lipoproteins, and also i …

载脂蛋白A-IV(apoA-IV)是一种能抗动脉硬化、抗氧化的糖蛋白。 目前对于该标志物的研究发现，血浆apoA-IV水平升高主要见于慢性肾脏疾病(CKD)或肾功能衰竭患者。

2018年9月6日 · Here we show that apolipoprotein A-IV (apoA-IV) can be isolated from human blood plasma using platelet β3 integrin-coated beads. Binding of apoA-IV to platelets requires activation of...

2019年4月5日 · Apolipoprotein A-IV (apoA-IV) is a lipid-binding protein, which is primarily synthesized in the small intestine, packaged into chylomicrons, and secreted into intestinal lymph during fat absorption. In the circulation, apoA-IV is present on chylomicron remnants, high-density lipoproteins, and also in lipid-free form.