载脂蛋白E - 百度百科
载脂蛋白E（apolipoprotein E，ApoE）是一种多态性蛋白，其是人体内最重要的脂质转运蛋白，也是对脂质代谢（主要是甘油三酯和胆固醇）影响最大的载脂蛋白。1973年，Shore等人最早发 …
Apolipoprotein E - Wikipedia
Apolipoprotein E (Apo-E) is a protein involved in the metabolism of fats in the body of mammals. A subtype is implicated in Alzheimer's disease and cardiovascular diseases. [5] . It is encoded in …
ApoE 基因相关科普 - 知乎 - 知乎专栏
载脂蛋白E （Apolipoprotein E, APOE）是人体一种非常重要的多态性蛋白，是一种含有299个氨基酸的单链多肽糖蛋白，主要存在于极低密度脂蛋白（VLDL）、乳糜微粒（CV）和高密度脂蛋 …
APOE Gene - GeneCards | APOE Protein | APOE Antibody
2024年12月24日 · APOE (Apolipoprotein E) is a Protein Coding gene. Diseases associated with APOE include Lipoprotein Glomerulopathy and Hyperlipoproteinemia, Type Iii. Among its …
Nature子刊综述：APOE家族与阿尔兹海默的相爱相杀 - 知乎
载脂蛋白e（apoe）是一类糖蛋白，参与脂质代谢调控，在中枢神经系统中广泛表达于星形胶质细胞、小胶质细胞和血管壁细胞以及脉络丛细胞。 apoe有三个等位基因突变体，分别是apoe*ε2 …
Cell：脂质化ApoE-受体相互作用减少为阿尔兹海默症的关键保护 …
载脂蛋白E （APOE）基因型是迟发性阿尔茨海默症（LOAD）最显著的遗传修饰因子，相对于更常见的 APOE3 等位基因， APOE4 和 APOE2 等位基因分别显著增加和降低疾病风险。 ApoE …
Decreased lipidated ApoE-receptor interactions confer protection ...
2024年11月11日 · In this study, we used artificially lipidated ApoE containing only 1–2 lipid species, which does not capture the complexity of brain ApoE lipoproteins. Our study focuses …
APOE gene - MedlinePlus
The APOE gene provides instructions for making a protein called apolipoprotein E. This protein combines with fats (lipids) in the body to form molecules called lipoproteins. Lipoproteins are …
Apolipoprotein E and Alzheimer disease: pathobiology and ... - Nature
2019年7月31日 · The apolipoprotein E (APOE) gene has three major allelic variants, APOE*ε2, APOE*ε3 and APOE*ε4; APOE*ε4 is associated with an increased risk and lower age of onset …
Apolipoprotein E and Alzheimer disease: risk, mechanisms, and …
Apolipoprotein E (ApoE) is a major cholesterol carrier that supports lipid transport and injury repair in the brain. APOE polymorphic alleles are the main genetic determinants of Alzheimer …