The Appel reaction is an organic reaction that converts an alcohol into an alkyl chloride using triphenylphosphine and carbon tetrachloride. [1] The use of carbon tetrabromide or bromine as a halide source will yield alkyl bromides, whereas using carbon tetraiodide, methyl iodide or iodine gives alkyl iodides.

Appel Reaction. The reaction of triphenylphosphine and tetrahalomethanes (CCl 4, CBr 4) with alcohols is a ready method to convert an alcohol to the corresponding alkyl halide under mild conditions. The yields are normally high.

In 1983, Harrison et al. studied in detail the polymer supported Appel reaction converting alcohols into alkyl chlorides using CCl4 and a PS-TPP support P-50 (P). After the reaction, they identified phosphine oxide P-50 (PO) as well as ylidic P-centers P-50 (P + C −).

2014年3月24日 · The Appel reaction converts primary and secondary alcohols into corresponding alkyl halides. The reaction is suitable for both acid- and base-sensitive alcohols since the reaction conditions are neutral.

Appel Reaction. The Appel reaction typically is described as PPh3 + CBr4. However, other bromine sources (ex. Br2 or NBS) are also used in conjunction with PPh3 to affect the same transformation. The mechanism is SN2 and results in the inversion of stereochemistry. [1]

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The Appel reaction is an organic reaction used to convert an alcohol to an alkyl halide using a tetrahalomethane and triphenylphosphine. The reaction begins with the halogenation of triphenyl-phosphine followed by the formation of the alkoxide from the alcohol starting material.

Example procedures for the conversion of an alcohol to a bromide using the Appel Rxn.

The Appel reaction is a mild method of halide introduction, and is successful on primary, secondary, and most tertiary alcohols. The use of carbon tetrabromide or bromine as a halide source will yield alkyl bromides, while using methyl iodide or iodine will give alkyl iodides.

The Appel Reaction converts an alcohol to an alkyl halide using a tetrabromide (CBr4) or tetrachloride (CCl4) combined with triphenylphosphine (PPh3) used as in catalytic quantities. This reaction is similar to the PBr3/SOCl2 reactions and differs from the HX (HBr/HCl/HI etc...) reactions as it will not lead to rearrangement for secondary alcohols.