2024年12月24日 · AREG (Amphiregulin) is a Protein Coding gene. Diseases associated with AREG include Ovarian Cystadenoma and Lymphangioma. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway. Gene Ontology (GO) annotations related to this gene include cytokine activity and …

Amphiregulin, also known as AREG, is a protein synthesized as a transmembrane glycoprotein with 252 aminoacids and it is encoded by the AREG gene. [5][6][7] in humans. [8] The protein encoded by this gene is a member of the epidermal growth factor (EGF) family. [5]

双调蛋白 (Amphiregulin, AREG) 是一种表皮生长因子 (EGF) 样分子，属于EGF家族。 它是一种自分泌生长因子，也是星形胶质细胞、雪旺细胞和成纤维细胞的有丝分裂原。

Amphiregulin (AREG), which acts as one of the ligands for epidermal receptor growth factor receptor (EGFR), plays a crucial role in tissue repair, inflammation, and immunity. AREG is synthesized as membrane-anchored pre-protein, and is excreted after proteolytic cleavage, and serves as an autocrine …

Amphiregulin (AREG) is a ligand of the epidermal growth factor receptor (EGFR), a widely expressed transmembrane tyrosine kinase. AREG is synthesized as a membrane-anchored precursor protein that can engage in juxtacrine signaling on adjacent cells.

The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha).

In humans, 2 copies of the AREG gene (AREG and AREGB) are found at the EGF family gene cluster on chromosome band 4q13.3, spanning about 10 kb of genomic DNA and located 160 kb apart. The 2 AREG genes are respectively linked to the betacellulin (BTC) genes at the 3 “region and the epiregulin (EREG) and epigenetic (EPGN) genes at the 5” region.[7] .

2025年2月9日 · identify the gene for the epidermal growth factor receptor (EGFR) ligand amphiregulin (AREG) as a transcriptional target of YAP, whose induction contributes to YAP-mediated cell proliferation and migration, but not mesenchymal transition.

Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts. AR is a protein containing cysteines in disulfide linkage (s) that are essential for its biological activity.

The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor ( EGF ) and transforming growth factor alpha ( TGF-alpha ).