2024年9月5日 · We showed that amphiregulin (AREG) expression is significantly elevated in intermediate alveolar stem cells of mouse fibrotic lungs and IPF patients. High levels of serum AREG correlate significantly with profound deteriorations in lung function in IPF patients.

- 主要发现：研究揭示了 中间型肺泡干细胞 （AT2细胞）中持续表达的amphiregulin（AREG）在推动肺纤维化进展中的关键作用，并提出AREG作为IPF疾病严重程度的潜在指标。 - 研究意义：通过使用 中和抗体 阻断AREG，可以有效抑制小鼠肺纤维化的发展，为治疗纤维化疾病提供了新的治疗策略。 - 中间型肺泡干细胞的分布与纤维化进展密切相关。 - 肺泡干细胞中持续的AREG表达是推动纤维化的必要且充分条件。 - IPF患者血液中AREG水平的升高与疾病严重程度显著相关 …

2023年3月6日 · Lung regulatory T (Treg) cells are critical for maintaining blood oxygenation following influenza virus infection through production of the EGFR ligand amphiregulin (Areg); however, how Treg cells engage with progenitors within the alveolar niche is unknown.

2021年7月27日 · Combining biophysical, genetic, and signaling analyses of primary airway epithelial cells, we demonstrate that healthy and IPF airway epithelia are biophysically distinct, identifying pathologic...

Studies have shown that macrophages produce a high level of AREG in lipopolysaccharide-induced acute lung injury, activate the EGFR-AKT pathway, inhibit inflammatory cell infiltration and inflammatory factor expression, and have a protective effect on lung tissue.

Amphiregulin (Areg) is an epidermal growth factor receptor (EGFR) ligand suggested to regulate airway injury and repair. We sought to determine whether Areg expression increases in CLAD, localize the cellular source of Areg induction in CLAD, and assess its …

2022年12月28日 · In this study, we demonstrated that expressions of AREG and FN increased in lung sections from OVA-sensitized mice, which were used as an asthma model. Moreover, colocalization of AREG and FN was observed in alveolar tissues. This indicated that AREG was associated with lung fibrosis and the alveolar EMT in asthmatic mice.

EGF, TGF-α, AREG and EPG only interact with ErbB1, while EREG, BC and HB-EGF bind to ErbB1 and ErbB4. A heterogeneous group of ligands called neuregulins (NRG) interacts with ErbB3 and ErbB4 [15] (Figure 1).

2024年9月28日 · In this report, we created a novel reporter mouse to detect Areg expression in live cells ( Areg Thy1.1 ). We employed influenza A and bleomycin models of lung damage to sort Areg-producing and -non-producing Treg cells for transcriptomic analyses.

2021年7月14日 · Amphiregulin (AREG), a ligand for epidermal growth factor receptor, is known to have essential roles in wound repair and inflammation resolution; furthermore,...