By exploiting a 3D co-culture model, we determined that AREG promoted SKP stemness by enhancing both proliferation and hair-inducing capacity through the PI3K and MAPK pathways. These findings suggest AREG therapy as a potentially promising approach for treating alopecia.

2022年8月1日 · Amphiregulin (AREG) plays an essential role in the metastasis and angiogenesis of various cancers. The objective of this study was to investigate the pharmacological effects of celastrol on AREG expression in triple-negative breast cancer (TNBC) cells. We analyzed the prognostic value of AREG, EGF, TGFA, and HB-EGF mRNA expression in TNBC patients.

2024年10月19日 · We observed an increase in the expression and secretion of amphiregulin (AREG) and the expression and phosphorylation of its receptor EGFR in co-cultured ESCC cells. Moreover, AREG treatment of ESCC cells enhanced their survival and migration via the EGFR-Erk/p38 MAPK signaling pathway.

2024年10月19日 · This study demonstrates that direct contact between MSCs and ESCC cells enhances AREG secretion from ESCC cells, promoting their survival and migration through activation of the EGFR-Erk/p38 MAPK signaling pathway. Additionally, AREG promotes MSC migration and differentiation into CAFs.

使用蛋白质印迹分析核转录因子 kappa-B (NF- κ B) 和丝裂原激活蛋白激酶 (MAPK)，包括细胞外信号调节激酶、c-Jun N 末端激酶和 p38 丝裂原激活蛋白激酶。 结果。

2023年6月6日 · 双调蛋白 (Amphiregulin, AREG) 是一种表皮生长因子 (EGF) 样分子，属于EGF家族。 它是一种自分泌生长因子，也是星形胶质细胞、雪旺细胞和成纤维细胞的有丝分裂原。

2023年4月25日 · Transcriptomic analyses of LY6D + luminal cells identified an autocrine positive feedback loop, based on the secretion of amphiregulin (AREG)-mediated activation of mitogen-activated protein kinase (MAPK) signaling, increasing cellular fitness and organoid formation.

2024年6月14日 · In this study, we discovered the unique contribution of stromal AREG to tumor malignancy, especially drug resistance acquired from the treatment-damaged TME, and demonstrated the potential of targeting AREG in combination with classic chemotherapy to improve therapeutic index.

2021年8月1日 · AREG is a potential therapeutic target in EGFR-driven epithelial ovarian cancer (EOC). AREG-stimulated migration, proliferation of EOC cells is independent of MAPK signaling. Endogenous AREG mediates EGFR-related migration and proliferation in EOC.

2023年10月11日 · AREG significantly increased the expression of IL-6 and IL-1β and the production of NO, PGE2, and IL-8 in HepG2 cells. It also activated the protein expression of iNOS and COX-2. AREG-activated NF-κB and MAPKs signaling, and together with NF-κB and MAPKs inhibitors, AREG significantly reduced the protein expression of iNOS and COX-2.