2019年10月1日 · In this study, over expression of AREG in MGC803 and SGC7901 GC cells were conducted by gene transfection through utilizing gateway recombinant cloning technology. Meanwhile, AREG knocked down in BGC823 and MKN45 GC cells were achieved by lentvirus-mediated shRNA oligos infection.

2024年9月28日 · In CRC cells, SALL4 downregulation suppressed AREG expression, regulating CRC cell radiosensitivity via the PI3K-AKT pathway, thus presenting a potential therapeutic pathway for CRC treatment using Radiotherapy (RT).

Medium supernatants conditioned by K-RASmt tumor cells equally efficiently stimulated EGFR signaling into the PI3K-AKT and mitogen-activated protein kinase pathways. Knocking down K-Ras expression by specific small interfering RNA markedly affected autocrine production of AREG, but not PI3K-AKT signaling, after treatment of K-RAS-mutated or ...

2024年6月14日 · In this study, we discovered the unique contribution of stromal AREG to tumor malignancy, especially drug resistance acquired from the treatment-damaged TME, and demonstrated the potential of targeting AREG in combination with classic chemotherapy to improve therapeutic index.

Areg overexpression activated PI3K/AKT pathway, and the addition of p-AKT inhibitor MK2206 reversed the activation. Conclusion: Areg promotes the proliferation of ATDC5 cells, and partially stimulates the osteogenic differentiation of ATDC5 cells via the PI3K/AKT pathway.

2019年1月1日 · The AREG siRNA markedly attenuated PM-induced inflammation and mucus hypersecretion, and activation of the EGFR-AKT/ERK pathway. Exogenous AREG significantly increased the expression of IL-1α, IL-1β, and Muc-5ac, and induced activation of the EGFR-AKT/ERK pathway in HBECs.

2024年1月1日 · 本研究的创新点在于揭示了SALL4通过调控AREG表达来影响CRC细胞对放射治疗的敏感性，并通过PI3K-AKT信号通路进行调节。 这一发现为CRC的放射治疗提供了新的潜在治疗途径，有助于提高放射治疗的效果，减少治疗抵抗，为结直肠癌患者带来更好的治疗前景。

AREG plays a vital role in biological processes through its interaction with EGFR and tyrosine phosphorylation of downstream proteins, activating two major signaling pathways, the MAPK and PI3K...

In CRC cells, SALL4 downregulation suppressed AREG expression, regulating CRC cell radiosensitivity via the PI3K-AKT pathway, thus presenting a potential therapeutic pathway for CRC treatment using Radiotherapy (RT).

2021年3月8日 · We classified EGFR pathway inhibitor types and investigated the type of biomarker (biomarker on epigenetic, DNA, mRNA or protein level). Several EGFR-PI3K-AKT-mTOR-pathway inhibitor biomarkers have been researched for HNSCC but few of the investigated biomarkers have been adequately confirmed in clinical trials.