Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function.

2024年12月24日 · ARG1 (Arginase 1) is a Protein Coding gene. Diseases associated with ARG1 include Argininemia and Urea Cycle Disorder . Among its related pathways are superpathway of L-citrulline metabolism and Innate Immune System .

Arginase (EC 3.5.3.1, arginine amidinase, canavanase, L-arginase, arginine transamidinase) is a manganese -containing enzyme. The reaction catalyzed by this enzyme is: It is the final enzyme of the urea cycle. It is ubiquitous to all domains of life. Arginase belongs to the ureohydrolase family of enzymes.

In growing tumors, TAM are often referred to as M2-like macrophages, which are cells that display immunosuppressive and tumorigenic functions and express the enzyme arginase 1 (Arg1).

2024年2月13日 · The ARG1 gene provides instructions for producing the enzyme arginase. This enzyme participates in the urea cycle, a series of reactions that occurs in liver cells.

2023年4月11日 · Learn about Arginase-1 Deficiency, including symptoms, causes, and treatments. If you or a loved one is affected by this condition, visit NORD to find.

2004年10月21日 · Arginase deficiency in untreated individuals is characterized by episodic hyperammonemia of variable degree that is infrequently severe enough to be life threatening or to cause death. Most commonly, birth and early childhood are normal.

2025年2月8日 · Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function.

2025年2月8日 · ARG1 (arginase 1) is a novel gene for acute brochodilator response in both children and adults with asthma. Arginase-1 is expressed and functionally important for collagen deposition in lung fibroblasts.

2021年7月19日 · Arginase 1 (ARG1) is a cytosolic enzyme that cleaves L-arginine, the substrate of inducible nitric oxide synthase (iNOS), and thereby impairs the control of various intracellular pathogens. Herein, we investigated the role of ARG1 during infection with Salmonella enterica serovar Typhimurium (S.tm).

Arginase 1 Deficiency (ARG1-D) is a rare, progressive, inherited disease that typically presents in childhood. It is an inherited disorder that affects children, teens and adults, and may significantly impact a patient’s health over time. ARG1-D is characterized by complete or partial lack of the enzyme arginase in the liver and red blood cells.

2022年10月8日 · There are two isoforms of arginase: arginase 1 (ARG1), which is expressed in the cytosol, and arginase 2 (ARG2), which is mainly located in the mitochondria. Although there are approximately 60%...

ARG1, which encodes Arginase1, is expressed in the liver cytoplasm and plays a major role in the hepatic urea cycle. The past research works shed light on the fact that ARG1 participates in anti-inflammation, tumor immunity, and immunosuppression-related diseases.

ARG1 is a cytosolic enzyme expressed in the liver, and the closely related isoform ARG2 is a mitochondrial enzyme found in diverse number of cells. In the tumor environment ARG1 is highly expressed in, and secreted by, the immunosuppressive MDSCs and TAMs.

2025年2月8日 · Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function.

2018年11月12日 · In growing tumors, TAM are often referred to as M2-like macrophages, which are cells that display immunosuppressive and tumorigenic functions and express the enzyme arginase 1 (Arg1).

2006年11月28日 · Arginase 1 (ARG1) metabolizes arginine to ornithine and thereby reduces extracellular arginine at sites of infection. 1 By depleting nitric oxide synthase (NOS) of its substrate, ARG1 leads to reduced synthesis of nitric oxide (NO), which plays a pivotal role in wound healing and immune responses. 1-6 Depletion of arginine by ARG1 released from ...

Collectively, ARG1 could worsen immunosuppression and vascular dysfunction during sepsis, leading to the poor prognosis, which is in accordance with our findings. To further verify the role of ARG1 as a key biomarker, we analyzed more datasets representing more populations.

The ARG1 gene provides instructions for producing the enzyme arginase. This enzyme participates in the urea cycle, a series of reactions that occurs in liver cells.

2016年4月4日 · Here we demonstrate that expression of the enzyme arginase-1 (Arg1) during acute or chronic lung inflammation is a conserved trait of mouse and human ILC2s. Deletion of mouse ILC-intrinsic...