2024年2月20日 · HGT contributes to the environmental adaptation of activated sludge bacteria. Transfers of ARGs and VGs were detected frequently in activated sludge bacteria. MGEs are important contributors to ARGs and VGs. Activated sludge (AS) plays a vital role in removing organic pollutants and nutrients from wastewater.

ARGs是一种新型、持久性的环境污染物，细菌中携带ARGs的质粒、整合子以及转座子等可在同种属菌株间和不同种属的菌株间发生水平基因转移（Horizontal genetransfer，HGT），即使抗性菌株死亡后，携带ARGs的裸露 DNA会在脱氧核苷酸酶的保护作用下长期存在。

2023年1月15日 · Horizontal gene transfer (HGT) is the main pathway for ARGs to lead to environmental threats. Therefore, the inhabitation of ARGs' HGT can effectively inhibit ARGs' potential drug resistance risk within a single strain.

2022年6月2日 · We propose a new pipeline, HT-ARGfinder, which detects horizontally transferred ARGs from metagenomic data derived from complex environmental microbial communities. The pipeline was applied to metagenomes obtained from a range of wastewater samples, representing presumed hotspots for ARG evolution and mobilization.

2021年5月12日 · 在这里，我们研究了水平基因转移 (HGT)的速率和靶点在不同工业化范围内的15个人类种群的数千株细菌中差异的程度。 结果发现，在最近几代宿主中，HGT在微生物群中积累，HGT在个体中发生的频率很高。 通过对人群的比较发现，工业化生活方式与较高的HGT率相关，HGT的功能与宿主的工业化水平相关。 我们的研究结果表明，肠道细菌在宿主生活方式的基础上不断获得新的功能，HGT的高发生率可能是人类历史上与工业化有关的最新发展。 1 来自 …

2024年6月14日 · HGTs of ARGs occurred more prevalently in sediments (six ARGs in sand) than in microplastics (six ARGs in stone, two ARGs in wood, two ARGs in PP and no ARG in PE).

2024年12月1日 · These studies consistently highlight microbial community evolution and horizontal gene transfer (HGT) are the primarily factors driving the fate of ARGs. The horizontal transfer of ARGs is recognized as a key contributor to their dissemination, with conjugation, transduction, and transformation being the primary mechanisms (Zhang et al., 2022).

2024年8月8日 · Moreover, HGTs can accelerate the global dissemination of antibiotic resistance genes (ARGs) among microbes (4, 8, 9). For example, Staphylococcus aureus acquired the vancomycin-resistant gene from Enterococcus faecalis through HGT (10, 11).

resistance genes (ARGs), which poses a serious threat to public health, is primarily attributable to HGT through MGEs. This mini- review aims to provide an overview of the mechanisms by which MGEs mediate HGT in microbes. Specifically, the behaviour of …

2022年4月27日 · 污水处理厂受到各种各样的污染物影响，是抗生素抗性基因（ARG）的潜在储存库，有利于通过水平基因转移培养耐多药细菌（MRB）。 基于Nanopore的ARG和细菌群落分析表明ARG积累有利于MRB的产生。 英文标题： Occurrence of antibiotic resistance genes and multidrug-resistant bacteria during wastewater treatment processes. 中文标题： 废水处理过程中抗生素耐药基因和多重耐药菌的出现. 发表期刊： Science of The Total Environment. 影响因 …