2024年12月24日 · ARHGEF2 (Rho/Rac Guanine Nucleotide Exchange Factor 2) is a Protein Coding gene. Diseases associated with ARHGEF2 include Neurodevelopmental Disorder With Midbrain And Hindbrain Malformations and Choreatic Disease. Among its related pathways are p75 NTR receptor-mediated signalling and GPCR Pathway.

2022年11月5日 · ARHGEF2 is transcriptionally repressed by AR, and the AR-targeted therapy relieves this repression leading to ARHGEF2 up-regulation. In addition, experiments demonstrate that ARHGEF2...

Rho guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the ARHGEF2 gene. [5] [6] [7]

Our results highlight the crucial function of ARHGEF2 in human brain development and identify a mutation in ARHGEF2 as novel cause of a neurodevelopmental disorder. Overexpression of miR-194 downregulates the GEF-H1/RhoA pathway, inhibits melanoma cancer cell …

Rho/Rac 鸟嘌呤核苷酸交换因子 2： Rho GTP 酶在许多细胞过程中起着重要作用，这些过程由通过 G 蛋白偶联受体起作用的细胞外刺激物启动。编码的蛋白质可能与 G 蛋白形成复合物并刺激 rho 依赖性信号。已经识别出编码不同亚型的可变剪接转录本变体。[RefSeq 提供，2009 年 6 月]

2022年7月27日 · Elevated ARHGEF2 accelerates HCC angiogenesis via the EDN1 pathway, enhances HCC cell proliferation and tumor growth both in vitro and in vivo, and contributes to ER stress-related treatment...

To test whether the genetic removal of Arhgef2 affects neurite branching and synapse formation during neural differentiation, we examined the morphology of cortical neurites and dendrite spines in adult Arhgef2−/− mice. Golgi staining demonstrated that the spine density and length were significantly below the level of those of wild-type ...

The PAR-1-MARK pathway controls cell polarity through the phosphorylation of microtubule-associated proteins. The Rho-Rac guanine nucleotide exchange factor 2 (ARHGEF2), which activates the ras homolog family member A (RHOA), is anchored to the ...

2024年3月5日 · Title: High ARHGEF2 (GEF-H1) Expression is Associated with Poor Prognosis Via Cell Cycle Regulation in Patients with Pancreatic Cancer. The RhoA regulators Myo9b and GEF-H1 are targets of cyclic nucleotide-dependent kinases in platelets.

ARHGEF2 (synonym GEF-H1, murine Lfc), a member of the Rho guanine nucleotide exchange factor family, is crucial for controlling the spatiotemporal activation of Rho GTPases (Ren et al., 1998; Krendel et al., 2002).