An aging-related cell-surface oxidase (aging-related NADH oxidase, arNOX) generating superoxide and other reactive oxygen species is shed from the cell surface and is found in saliva, urine, perspiration, and interstitial fluids that surround the collagen and elastin matrix underlying dermis. arNOX activity correlates with age and reaches a ...

2016年9月29日 · The discovery of a family of cell surface age-related ECTO-NOX proteins, designated as arNOX or ENOX3 capable of generating superoxide which can then dismutase to form hydrogen peroxide as well as the directly oxidized tyrosines and protein thiols, has led …

2015年1月1日 · An aging-related ENOX protein arNOX (ENOX3) of the cell surface and endosomes shed into body fluids increases in activity linearly with age beginning at about 30 years to a maximum at about age 65. Subjects surviving beyond age 65 …

arNOX (ENOX3) activity of skin increases with age beginning at age 30 as determined for both dermis and epidermis . The arNOX generates superoxide and reactive oxygen at the cell surface, significantly increasing the ratio of production of reactive oxygen species (ROS) …

2014年6月7日 · Age-related NADH oxidase (arNOX), a cell surface-located hydroquinone oxidase capable of superoxide generation, appears at age 30 and increases with age thereafter.

2013年7月24日 · The newly identified arNOX enzyme appears to be related to age and appearance, and may be implicated in the internal aging process via the production of superoxide free radicals. This work demonstrates that arNOX activity is found in both the epidermis and dermis, and draws a correlation between the enzyme’s activity and an aged appearance.

Our work has identified an aging-related ECTO-NOX activity (arNOX), a hydroquinone oxidase which is cell surface located and generates superoxide. This activity increases with increasing age beginning >30 y.

By generating reactive oxygen species at the cell surface and in body fluids (saliva, serum, perspiration, urine), arNOX provides a mechanism to propagate reactive oxygen species at the cell surface to surrounding cells as occurs in skin aging and to circulating serum lipoproteins of importance to atherogenesis.

2012年1月1日 · The classification of arNOX proteins as ENOX proteins is based on functional similarities of arNOX to ENOX1 and ENOX2 in that hydroquinones or semiquinones are electron donors for the cell surface form of the protein and molecular oxygen is an electron acceptor. arNOX proteins differ by generating superoxide during a portion of the activity cycle.

2015年8月13日 · In this study serum arNOX activity was not directly responsive to the presence of knee OA. However, arNOX activity was consistently higher in senescent, defective, profoundly hypoxic and glycolytic cartilages, and in OA with severe or extensive radiographic bony change.