
Arp2/3 complex - Wikipedia
Arp2/3 complex (Actin Related Protein 2/3 complex) is a seven-subunit protein complex that plays a major role in the regulation of the actin cytoskeleton. It is a major component of the actin cytoskeleton and is found in most actin cytoskeleton-containing eukaryotic cells. [ 2 ]
Arp2/3复合体 - 百度百科
Arp2/3复合体(英语:Arp2/3 complex)是一个包含7个次单元的蛋白质,专门调控 肌动蛋白 (actin) 细胞骨架。 其中Arp2与Arp3属于肌动蛋白相关蛋白(Actin-Related Proteins),能对微丝进行核化(nucleation)。 整个复合体则能够与微丝结合,并且使促使新的微丝生成。 Arp2/3复合体呈椭圆形,长约15nm、宽约14nm,厚约7-10nm ,由七条保守的多肽链组成。 其中,ARP2与ARP3两个亚基,为肌动蛋白相关蛋白(actin related protein),另外5个亚基按照 …
The ARP2/3 complex: an actin nucleator comes of age
2006年10月1日 · The ARP2/3 complex regulates the initiation of actin polymerization and the organization of filaments into y-branched networks.
ACTR2 Gene - GeneCards | ARP2 Protein | ARP2 Antibody
2024年12月24日 · ACTR2 (Actin Related Protein 2) is a Protein Coding gene. Diseases associated with ACTR2 include Wiskott-Aldrich Syndrome and Peroxisome Biogenesis Disorder 6B. Among its related pathways are Regulation of actin dynamics for phagocytic cup formation and Actin Nucleation by ARP-WASP Complex.
Arp2/3复合体 - 维基百科,自由的百科全书
Arp2/3复合体 (英语: Arp2/3 complex)是一个包含7个次单元的蛋白质,专门调控 肌动蛋白 (actin) 细胞骨架。 其中Arp2与Arp3属于肌动蛋白相关蛋白(A ctin- R elated P roteins),能对 微丝 进行核化(nucleation)。 整个复合体则能够与微丝结合,并且使促使新的微丝生成。
Arp2/3複合體 - 维基百科,自由的百科全书
Arp2/3複合體 (英語: Arp2/3 complex)是一個包含7個次單元的蛋白質,專門調控 肌動蛋白 (actin) 細胞骨架。 其中Arp2與Arp3屬於肌動蛋白相關蛋白(A ctin- R elated P roteins),能對 微絲 進行核化(nucleation)。 整個複合體則能夠與微絲結合,並且使促使新的微絲生成。
Sci Adv丨徐孟琦发现肌球蛋白与Arp2/3复合体合作调控
2024年9月22日 · Arp2/3复合体是一种由七个亚基组成的蛋白质复合体,其主要功能是促进肌动蛋白分支的形成。当Arp2/3复合体被成核促进因子 (nucleation promoting factors, NPFs) 激活时 (如WASP/WAVE家族蛋白) ,它会附着在现有的母丝 (母肌动蛋白丝) 的一侧,促使新肌动蛋白丝 …
Mechanism of synergistic activation of Arp2/3 complex by
2023年10月28日 · Nature Communications - Arp2/3 complex is activated by nucleation promoting factors (NPFs) to form actin branches that are stabilized by cortactin. Here, the authors show that NPFs and...
Molecular mechanism of Arp2/3 complex activation by nucleation …
Arp2/3 complex is natively inactive and must undergo large conformational changes to transition into the active state in the branch junction. Proteins called nucleation-promoting factors and actin filaments assist in branch formation but their mechanisms are incompletely characterized. Our molecular dynamics simulations of several cryo-electron ...
NPF binding to Arp2 is allosterically linked to the release of
Arp2/3 complex generates branched actin filament networks crucial for numerous motile functions of the cell. Factors driving Arp2/3 complex activation include ATP, nucleation-promoting factors (NPFs), monomers, and filaments, but the individual contribution of each factor is masked within the overall conformational change occurring during activation.